Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

t05.65% Th. |@rst ddic. of bo$ rt drug' clarty stow.d rt|tt d inra.dion.r |Iy pH
bv.h Ou! both {E dosr c@ld bc d.ly 6.tnini!tq!d.
DI
t4ktu 4nnt oJ 4dtur rhh dtt@- tu w tp.dtupteto&nr @d EpLa
pH9
HPLC HPII HPLC urrr
%.la
t5 98 35 97.42
l@.02 101.22 99 55
105.75 l(x) 96 r@.03 l@tl 101.43
92.t5 t02.65 10016 l03.la
93 5t lm 5.t
t00.69 9t.36 t0t.23 l0l.2l
t05 102.15 9a l'l
120 y, t5 r@.J6 93.13 101.37 t(D.63
0 Iot .}t tm.9l 93. t3 rot.n
t5 1m.56 100.87 l0l 16 1m.85 9t.36 101.23
t01.26 22 I02 35
102.5a 100.68 %.tJ
l&99 96.1,t l@31 yr.t2 l@ 33
15 102.54 l0l.2l 10t.57 100 36 93.41
l0l. q_tl rct.n tot.92
t00.03 100.26
tm 9125
Th. Niru6 3pc.r..l ri8fi,tr fo..blodipi@.t dl
th. pn le obkEd b be !r 366 !|d 236m.
IIde h ordr io strc rh. ddiqtiv. sp€r. of
cdiri2i@ .rd .Dtodipin it|. fiis &ivdiE
lp€ro@pic t€hriq@ wa .ppli.d. A,.lrricd
ng..|3 n6!r&d 1 pH 1 fo. cai.izi@ &d
mroi'F4 rc.! 225.t 19.d 23r a3 @. r pn
ll - !/a\
n..E 3.2rr DeridtiE Srcn dcc .Dd r,il
4,2ta.M @ 2t9.tZ, tt pttT.4 rhe .DtFicrl esrct.tgrt Fl.dd *$ 22.9t at! 210.74 m
!,.t .r plt 9 ir $.! d 224.95 ud 2t9.53 m (fi8@ 3 24). Th. Gg.eion r.ri!ri..! e
-
95