Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
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d ephthyld<strong>in</strong> . Th. rca.tion mh&bm for th. fm.tion <strong>of</strong> atirizirc d.rivarives follow.d<br />
nrclophidc subsdtution re&tion3. Th. piodwr. obtr<strong>in</strong>cd wft.hdet ri2.d by FT-IR rH-<br />
NMR od rc specroi$<br />
'll'.$ d.rivativcs w€E furrha subjercd for lh. posibt. eti<strong>in</strong>U.maiory miiviry .s r€l.s<br />
<strong>of</strong> hjri.nift dd podrction <strong>of</strong> crlotie by mst c.lb {d bephih e thoudt ro b. doely<br />
<strong>in</strong>slrcd <strong>in</strong> Uc p.thog.eeis <strong>of</strong> .llclgic dis.es. All.Eic dilcdg my <strong>in</strong>volv. irfl'mlrory<br />
Dediatoa 3rch a hisi.nirc, .ttoLiFs ed msy difIGMr c.ll rtlcs iNlud<strong>in</strong>s T c.ttsr oasr<br />
c.Un bqophils, n umphih, naophagG .r.. An etihist mic sho$ ori,<strong>in</strong>fl.lmliory<br />
efrecrs at thmp.uric conc.nr.tioN thn ruy nodiry !h€ .fla|3 <strong>of</strong> idmmabry bedi.roB tt<br />
r,w at dos @Bp.6ble !o 6os !s.d cl<strong>in</strong>ically. Lhiml .nleed chmilM<strong>in</strong>*r@ @y<br />
*w F.fodr.d, th. pal<strong>in</strong>iE y $tailg BuX! <strong>of</strong> wholc blood lnowd rhal .onlouds<br />
7t4, 119 &fl 121 .xlribn d sigrifimr oxiddiE burn Espo.3. (eri-i.flumarory) !r<br />
coNotltioB l.rcl <strong>of</strong> l00, 50, 12.5 F8nLi, Eiell.nr irhibirory &riviri6 <strong>of</strong> lt!*<br />
compo@dt wd @.dcd !r t2.5lrghli i... %, 92.5 snd 9t.E Eq.criv.ty. th€*<br />
@npounds *4 rhm l6rcd for a.dviri6 otr i$ldcd m&Fph.8. elts on liv. @nmr.riotu<br />
l*L 50,25. 12.5.6.1atd 3.llrgnfr. lr s found lh.r all ddvdrv€{hlv€.ettdr .tr{G<br />
m nll@ph.e6 .d G nuch |tm potan rha eririzjl. 6c.'r 7l a, Funh6<br />
phmolosicrl rctiviti.s @old fiMlly d.rmim lhcn.kr mhdism <strong>of</strong> edon .d .ner<br />
clrororic &ivni6 th* d.rirdiv.i could rdly povc cGllcfi rh.Epcutic !g6rs <strong>in</strong> arhm<br />
Ihc sbitivity <strong>of</strong> c.&izie ad its dqiEriv6 io r nonllolif.rdis .r!d tmlif.ntiv. BFn$<br />
ro r!. ditogsr phrto[.ba€8luril<strong>in</strong> (PHA) rad Bilogc.-ilduccd prelif.ati@ <strong>of</strong> Tlloplers<br />
M rt$ c!rl@&d. SuppBsiE .fcct <strong>of</strong> ohFurd 7l4 M obs.d.d o Tslt<br />
Folife..{o[ simild] 719 $o*!d .xellcnr Tall $ppr6sir &rivides- C@pould ?27<br />
shoved s <strong>in</strong>t mcdid. !.tiviIy. Th. Gulll fval.d rhn conDounds ?lr, 719 dd 727<br />
dhibiled dtic.Gr activity .rd @uld b. prcv.d l€ad coopoundr i. th.6p.uic qorld aRcr<br />
turha srudi6. AnihsrM<strong>in</strong>ic &livi(6 <strong>of</strong> rh.,Jb96 ompoundi @uld rci be @ndEl€d<br />
drc !o ler <strong>of</strong> fei{iry.<br />
1-,tr& lur'r,
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