Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

s€@ we obs.led to b. 0.04 l!gn[ 'and 0.15 llgnl- ' esp.criv€ly. Equiul.@ sludy w6
perfomed al difeEnl bmds ol celnizine rablets availdble jn Potjsllr The svajlabihy of
eii.izinc fion @n@rially wrilablc dosg. fo@ vft ..tculared (rdlc 3,4) dd w
foud to be in asebot *irh lhe lab.led claim!.
allco|et! o1(lnitk aJifere lqnulaho8 rn tE 7 4
r@j 96.23
t3.9 t008 93..18 97.25
97 27 92 t2 u.26 t2.t2
2lL t05 3 t0t.83 t0.2.78 t02.73
Mo@va, no pturou@d eff€d wo obsred in cG ofpH 1.2 ad
foud ro b€ pH indeF.denr i..., sc !r pH t.2 ud pH 7.4, The
on@halion l.vels in pH 7,4 (simulaine btood pH) wft sl€ded
ldr qwdtador of c.frizine in sfu. I1!. 6ov€ry val@s $
obrair.d @ givcn in bble 3.5 idi@tii8 suirability of melhod. Ite
etulls ofth€ abor nudy indicrd rtu tn dlrhod @utd b€.r,ptied
to stinale cdirizine in bul* dtue s wI 6 iD d6!s. fomuEioB
aal in sfu This h€lhod is doe Etiabte thd ot!.i tJv
speEophorohelric nelhodr &d it en@mgs onc io alply tor oulirc ellsis
B RP-qPLC reblho.
.1,2..t1 103,95
J6_9t 1 ,.2
HPLC is a *tuitile ed sFcific lahriqu. rhroush which pra@@kn€ric arudi€s ce be
@alucr.d on a lergc vdi.ty of rh.Ep.uric ag.rrs. ft ce ,le b. u.d foi cli c.t t€s@h and
for lhdnFuiic drDg monitoriog. A s.lecdve ed Epid HPLC Detnod 16 d.liFd for rhe
q@ril'rion of c€tntin in &tive, fmulaijoN &d hul@ sm. s,nulr.r€ou HPLC
nello& of c4irizine in pr6.nce of o ldministdr