Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

Ciptofl(eia @ein rd pc0oeir 6 im|!s rlsphylli!. @nqrllrioN 10 ioxic
vdB, atrnity of quirolores fq the ga|lddinobItldc &id 6.Fl0r nay indue CNS
adv* efrets [9sl. Quinolord have beo Epon d ro poss con{Isr &riviry [96-9].
4 Cd6M.h.nr.t ukttus
calciu chonel blockB e a hetercge@s sreup of dres 0lD, r0l I Fp|lgtilg a ldge,
siMff.lly di!re gbup of chdiqb l|i.13h& lle lbilfty ro inlibil calciu 6ry i o
nusl. c.ns tnftush &doo on rhe calciw-$l4dve ion llml. Th. ddss inclurted in |hi!
careso.y re phoylalkylminq (v€Bp.dil), bc@dj.apiE, (dilti@n), dihydopyidinc
(mlodipire). diarylminopopylmiE (tcpridil) t1031. v@pmil, diltim ed nicardipine
w fomd to inlibii h.ldic dug-m.t bolizjng .Dr-_ym. SMica on ircE tion b€tw*n
digoxin ed dlciM.h.@l bl@t6 shoped ihn vdrdil incrled pl.sm digoxile
@E@hrio6 [r04] Oth* inra!.tioB @udd in prt.ere of @t nu2.pie, cyctGporirc
and cinelidine have ale b.d rcporr€d 005-rl0l.
Trbl.l.3
caL.t@ bbta' vled.nh/ idenctiN l7t11l
(2S.lSf l r2 dindiylmiRrhyll2.l.4.5-bhhld@2{..ninoxy
Dh.nyl)4{rel,5-h.nrc diepim
.3.yle.Lt. h}dehlori&, rnjG,
crylbllin po*der, solubl. in a.&.,
m.0!rol rnd nedrylo. chldide,
dishlly slubL in .ttdol, h n.lE
1 atbul 2llcc with d..onm.ili@.
Alphllt-l P{ J.{-din.rhdtdEnrlLrhrl lDdnrbhirdprlpyU-J+
ndhylaiyl)a.nanaeroniril.;t.
(3,4ii-
Ddhox}?herelnyl)Bdhyldinol-2-
(3,4.dim.dbxyph.nyl>2.i$.
pFpylvaldnitilqcrH,NP. Flubl.
ii *d.r dd m.deol, sp.insly
-v
(r"
I -
2-l{2sinodno(}nndhylH.{2{hlotudbrl}r...dihtdrc-GD.rtyL
,,5-plddindio6oxylic *id r