Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
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RESULTS AND DISCUSSION<br />
The possibiliiy <strong>of</strong> druss ro <strong>in</strong>i uence each orhos sfety or emecy is <strong>tn</strong>oM as drug-drug<br />
ifletudon, Th€ esuhs <strong>of</strong>a r€ce.r Egi$ry stldy ildicated thal ar l.st 250,000 Fsos die<br />
q.h y@ 6 r E dr <strong>of</strong> @s Eade Btilc thcy e hospnaliad. 'Ilt. hnk <strong>of</strong> fice do6<br />
itrvolvcd nbadv€trtws pith lhmpeulic drugs 0E31. Drng i .r.clioB @nnonly @cu<br />
with multipls medications, may nate drug less e,Iecdve, csuse uncxp.cted side efTects. or<br />
ilqess lhe action <strong>of</strong> a panicule dsg. Son. ddg <strong>in</strong>tetutions 6 clen be hmtul dd hay<br />
bre pl&. due to @ion <strong>of</strong> dlugs with @h oth.r. This r'rusnrug <strong>in</strong>re@don my o@ to<br />
.xF i.n* & uexpelted sidc eff6a Dru-food,bev@g€ <strong>in</strong>tcnctios esuh from dnCr<br />
Eml<strong>in</strong>g wilh fmds o. b€v.rd8cs 0841. Most <strong>in</strong>te@tioG r€ma<strong>in</strong> t!@ognird b€cdue drugs,<br />
b gei.rrl, havc a wide ndgio <strong>of</strong> sfety or b€cause the exlenr <strong>of</strong> chdge <strong>in</strong> drug leveh is<br />
sall wh.n compded with vdiadon nomally s6 <strong>in</strong> cl<strong>in</strong>ical thdpy. All drw <strong>in</strong>tcdcions<br />
hat t phm@k<strong>in</strong>etic or phmaodylmic b6is [85]. on rh.s€ tes a pmc€duE rc<br />
adaptcd ro study the - vlz <strong>in</strong>lerulior olceiriz<strong>in</strong> *irh difreMr @ adnidstqed dDgs. Fo!<br />
thjs purpose diilf<strong>tn</strong>l sp€clrosopic lechniqu.s w.rc ued md conpoEd. S<strong>in</strong>ullaneous<br />
nethod! wer€ als d€v€lop€d dd vali.bt d tor th€ .lelemimtion <strong>of</strong> ednz<strong>in</strong>e <strong>in</strong> Pl€eoce <strong>of</strong><br />
dif€E dtues 6<strong>in</strong>s RP-HPLC lEhniqE. AI <strong>tn</strong> F n€thods wd late. on used 10 sludy rhe<br />
p6\iblcr, v,i.o <strong>in</strong>tetulion<strong>of</strong> er<strong>in</strong>ttr widdificrnt dngs<br />
A UY-Vilible3p..lolcopy<br />
aralysis <strong>of</strong> cdniz<strong>in</strong> hs b.d snrdi€d qt€6iv.ly by UV spetrcs@py [27-29] blt all $e$<br />
n rho
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