Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
c*boxyl grcup <strong>of</strong> cctirizilc ad edim hyd@xid. <strong>in</strong> 6qh6 mediu. Th€ lalidity <strong>of</strong> lne<br />
hetlDds M tuiher aerta<strong>in</strong>.d by pdallel detcnn<strong>in</strong>aiion s<strong>in</strong>g 6 Eferenc. melhod md by<br />
Eorc'l nudiq F2J. S<strong>in</strong>plc, prcis &d €cononicd rpelrphoroncEic nelho& *w<br />
develoD€d ior lhe simulla@s esiimtion ol cefiizift dd mbroxol <strong>in</strong> t bler fomulaioN.<br />
The 6d ndhod *6 brsd on th€ B <strong>of</strong> nultidmp<strong>of</strong>t mod€ urlysis dd sd nedod<br />
wa based on fist dailative sp€cual salysis, while lhe thnd De<strong>tn</strong>od was baed on Qoalysis,<br />
i... tlp ab$rba@ dlio merhod. Boln druss ob.yed B@"s la* <strong>in</strong> lhe 6I@!a!io.<br />
6ge <strong>of</strong> 5-10 ssDL-' for etiriz<strong>in</strong>e dd IG60 psml-' for dboxol [3]351. A derivative<br />
speEopholoneEic m.thod w6 ddcloped for 1h. asy ol thG biMry nixlws <strong>of</strong><br />
pstudo@hedr<strong>in</strong>e with fq<strong>of</strong>oadirc, cdiriz<strong>in</strong>e dd lonlad<strong>in</strong>€, nrc ne6od h bed on $e *<br />
<strong>of</strong> lhe nrsl d.dvativ. <strong>of</strong>lh. qlio spetrM [36].<br />
ii HiAhper|almrce th<strong>in</strong>larechrudatogtdpll, (HPTLC)<br />
A Epid od *6itiv. mTLC 6sy had been d.velopcd fo. the m6l!@dl <strong>of</strong> eririz<strong>in</strong>€ <strong>in</strong><br />
hmd plasnd dd irs utihy for phmek<strong>in</strong>eics srldy had b€d cvrl@red. In this nelhod<br />
q@tifi€ on M done vilh ihe h.lp <strong>of</strong> a d@l wvclcngd TCL @n.r. The prcpoFd<br />
tElhod had a Ecovery <strong>of</strong> 9E% an l Ur€ low.sl houl <strong>of</strong> c.tiriz<strong>in</strong>e thal €ould be d.t d.d ws<br />
50 ne. Thc medod *a applied for <strong>tn</strong>c d.ldielion <strong>of</strong> th. plasm lqel ed phjm@kirelic<br />
pdmeteB <strong>of</strong> cetriz<strong>in</strong>€ an€r oral adm<strong>in</strong>idration <strong>of</strong> lwo na*elcd pr@drtions <strong>in</strong> h.alhy<br />
vol@ie4, The deted<strong>in</strong>ed merhods eE <strong>in</strong> agenenl with previocly rcp<strong>of</strong>ted lalucs [37]<br />
Ps.ld6phdiift dd edriz<strong>in</strong> @ wid.ly uled <strong>in</strong> the remot <strong>of</strong> allergic ih<strong>in</strong>njs. A Fpid<br />
*lecdve &d slability <strong>in</strong>dic.t<strong>in</strong>e HPTLC m€rhod *6 develot d md rElidaled lor then<br />
s<strong>in</strong>ulrosN dekmimtion <strong>in</strong> phm@uricalr. The bernod dployed TLC al@<strong>in</strong>m plaret<br />
pr€c@ted wilh silica Sel u $e slarioney phse. The elvot syst€m onsisred <strong>of</strong> EIOAo-<br />
MCOH-NHj (7:1.5:l). Spetrc
Change language