Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

II\IRODUCTION
nisianitu is a subsree thar is widely dktriburcd io body tilsB &d d on k\
Elw ftod sronge sites. exen a vriery of phmlod".l "r"* "f ;]*
,a4,n8 'nknsu) HrtM nesR uru.lb rcspoNibl. ior alkl8r dsod*s,n Y
th€ body. Il stmulat s the prcdetion of nNN dd .lilafion of blod v.sb. I
sufra or.11..$/ @osda hi$rnie .fr.crs s r 'lmy nose dd smlLn nael pdesd {l I.
2 Uin6lr.4.pt4r
Hislanine bdns3 irs clf@r nmwl rhe e$vnid tw @prors, H, ed H, rtDi ditr rl oi tl)e
bais oftheii difiering ensiliviry ro agonin od mbgorists, Hr have been foud in b6ii [2]
Ht rcceptar dtaqonists
H1 r€cepto. slagonins compelililely bl@k nis@nine at Hr reeptor dd.d b. depicted o
suhslitut of .lhylmiE @Dpouds. Bov€r &d collabontoB pl ws€ th. fi61 *ho
disvcFd Hr Gcplor dragonisr* Aner itt disuy mdy @npounds sF fou.d io show
hi8} ar,sonist pocfty ar this deptor [4 s]. R6ulls ftom @ly snrdid wirh rh* analosou
dsiwtiv* of cthylcftdidire sueacsEd . clinjc€l potcnlial io. rc.ting .lLrgic ad
irnallrmb.r di&de6 [6].
In rhe b€siMing. thc rctiv€ hi$mine H | @.plor dtaeonists r,s s,6*n by a g.n 6l fomtna
onFisins two Nmadc sreuF [Dr.d by r shon chlin of
t" I I
c atod b ! l.ni.ry Mi@ sreDp. Arr is drlor h.r.re aryl, l-:-i-""'"'
I
\tich nay b.6[th.r subslintsl Al is *@na aryt,ingo.
" ^"
m aryl netrrl goup. The Mo aryl soup Arr dd Al @y be bnds.d |o fom ticlclic
derivativ6, X is a sp: or spr hybridized cebon, a niroeen or a spr @bon with d oxyee.
(€th€t [Dr coMecting the side chain ro the donaiic ringr, C-C r€psents a short chain of
cabon atom which may b€ sat@ted, uneturaLd, b@ched or fom pan of ring systen.
\R'R? t g46lly. Gniary dino ercup whi.h my bc pa.t of a nng 3t!i.n. tl ws loud
dEt activity @!ld b. iftEded nEk dly wiln the iftodwtiotr of a sond mtudc or
hetemyclic .ing i o rhc $tutur ad ths,ndbq of adlosB wa syndEsird and