Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

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9 C.dridn. ritn MDDMS I SituLtuous.letemiMtion otcetuxire in preprce of NIDDl,lt Tl}tph@t16 may prcfmntially ditr@ i.t€ lo*srds a Thl ebBF, which b thowht ro b€ involvcd in th. autoimre .spets ofdiabd.r or a In2 subtt!., whjch is thought ro d.dial€ aueryic dbeses [3{3]. orc of the sudies @nfim.d $. skin ndifesLtions of diab€Es n llits to b. a co@on @u!r!@ 'lquiring a sios appr@h &d Ednar It w Eval€d tbar pEv.L4 of diab.l6 Fllitu rclatcd stir disr
I! th. deib.d pc.d!n, sp{rtio of ildieidud NIDDMT t!qui!.d oodifi.tlid of th. hlf.r/oryeic aolvcd r.lio. Ho*vq, no mahod for siEult.FB d.t@i..lio of edririd i! plBdc of NIDDMS w nudi.d ro fr. InlI|? p|!s.! vqt..d RP-HPLC mdhod for siDull{|ds catitutioo of caidnrc in F*@ of mcdmiA sliquidom d|d glibcelcni& a dcElopcd. In th Fllininry qrdimnrs difrst tr.ri6 of dE iiobil. p[e *E t6r.d. h B ob.dcd rhll ntio @tukrins of (90:10) mrhdDl: qard R.8@bn notbls ct l witb r of tb 8!E @ sf.rolioE of F.ri b.t96 c.ttti4 dd Dcrftdi!. HG@ o{hd ddo! vw.l$ ti.d. TL &:20 su!.d in good symaricd F.lr wiu -api.bL 3?.mi6 .bons dl &ugi Hos.lq, dcBioe rhc &mul of hcihlsl fidtd in th. nobil. pt|'!c Bttrd ir itsgscd raqnio dDc for sliguidorc. H.ncc, r*o conpolrcd FobiL pha w chos.n for tE 3ndy. t w'! .le ob.dvcd d .djusi.s 0F pH of mbib plw ro 2.E Bltr.d i! oltr@d {.ltlc paL ryt|Way and !6oluti@ for ltl tb. .!s.ycd druss. Th. r.cn{on liB for mdomill cctirizi@, slibqFlui& ed gliqlidoc wc foud b b. 2.5, l,t, 5,5 rrd t2 niNt 3" n$.ctislr. ln lhk retlod diclolqE 3odtue q,!! r!.d a e inrdnrl lrllddd cluliog ord .r 7.5 rninqt6. Th. ..libr$ion crw6 for .ll dE dn$ wE @6h&Ld ud.r o?dhu @nditi@ &d dF li|Eiry of d! mthod w6 erBt d by Frfo.niq injetiom.l toa toD o.2r3 0,95 0.t69 o.26 0.01 0,(x)3 0.393 0.|l7 r|lLJ,Dj %RSD o.12 91,88 0,56 t0l_22 o.52 91,3t 807. 0.3 to2.1J l00tt 0.16 106.1 t20x 0.tl 10t,78 wl 0J,l 102.36 t@'4 0,6 l0t.8t 0.65 t0t.7'l 80tr o.52 t0t.t8 l00ra 0_J6 9,94 t20rl l00.l,a *q difr@nt con @lEtid l*b in thc lind mgc ov.r 2 diffctqr d.rs. Ttu D.d( !n$ of dl th. doa3 wa plo!.d lgrinsr lh. @FsFodi!8 lmiol @nc.oL|ri@ io obr.in cdibdrion gtlph. Th. @blion @mci@ls oad tt sitivity of dl dE ddSs v4 e!r.bli!h.d od e p@ncd h l!U. 3. | 14, Th. FgBid .qurriou obtdrEd for ncdmit! elniziE, slib@cbni& md sliqddo@ lw y-E0609(+38188, r=332E9x-t tEt6, F58303x-12E27 ald r {390x+51842, Fg.crisly. Thc sitivhy of lk &.t}ri.!t t2E
Page 1 and 2:
DRUG.DRUG INTERACTION STUDIES OF CE
Page 3 and 4:
llfris tfr-tis is &atcf to rtJ N6rr
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S.No Dadl3 B c D E B c D E Hisory H
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E F CairiziE witb NSA.ID'3 Sinuli'e
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l0 |l l2 RESEARCII PUBLICATIONS ANT
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ABERf,VIATIONS Alnl An odipine PMA
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d ephthyldin . Th. rca.tion mh&bm f
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INTRODUCTION
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€valutcd. The nosl aDnug smup is
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wilh l@g le*iDg .ctivily. h I ob*o
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sllbiliad by inta holecurd hydrcgd
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iii High pre$we liquid chtohatogaph
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kela.@n@le withoul ihc incEbed nlk
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C Int nctilgdrug! Cetinzine is wide
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Resfuh on 4{uinolon.-3.carboxyhr€
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3 Notst@idd .ttiJnfunmto,f dr.tt (N
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dslhma swh s coughinS, whezing, dd
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Hist.oc./melabolic s}t'dmne, which
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mirlende. rh. sErion of homones ed
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e$enrid fuciion ol cob.h is rs a co
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tdd hody kd.a d.r diliihdm ir tutld
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the h@d imw sysid pDi€ct lion dip
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u CwrhaealdttutirB Whia Dlood ard e
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Raw @&ituls a.d wft of Dtmr.uticd p
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AllD( 500 MHz spetron i.r sing IMS
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T.bl.2l LMit rdgd of@lra ob.yirls B
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solutiors. Con@.nadon tug€3 of al
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3 Dmg- dru! i .ncriob srndi6 The D
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la* dd HBSS+ *s !dd.d to @h wll to
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RESULTS AND DISCUSSION The possibil
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s€@ we obs.led to b. 0.04 l!gn[ '
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povatul My of optinizing sel*dvny \
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m. xrcjD ., d. t{31 dd€lop.d d R!
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Ruggedrs ol ihc medod @ hld.!.d by
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Hce, b = lldr logth of $e ell ( I c
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nin'mM detectable linit of 5 lenl,
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The develoted nelhod M lppli.d tor
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Irr &nltri.al nsim for feotidirc .t
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tbh aS9 Ituftti@ r.s,Ls otethxiE wi
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et dt. [22E] q@rifi.d rhe sinvlsrlr
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Intudide pr*iriN of the Ntho.l % RS
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tbn ct .[dtttEadtu r=ll3!7i+0.0017
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Tr! Mid risr.l ohriBt ftr l[. Fw.dr
Page 87 and 88: l :l &rF1(,: Chudo'u.of iGdon .r Ct
Page 89 and 90: 3 C.dddr. rttt qrbolon6 I Shrtt@Bd.
Page 91 and 92: Rerendon line obw.rl for ouinoton.s
Page 93 and 94: LaLt al t*tdhl nattqedtur dh lo@t6
Page 95 and 96: ft. r* ofofotuin .t pH I w fold ro
Page 97 and 98: Rcg$sion sbdnics re sboh in tablc 3
Page 99 and 100: T1E r'- of 3pd0oeir at pH I w'16I,
Page 101 and 102: M .@onim @tate. aceroniuile and l'i
Page 103 and 104: ihe ld.b of co@manon o. difrer d.F.
Page 105 and 106: .5t lt9 Itur@tt@ wltt ofqd^nN db tn
Page 107 and 108: .pfstd ttdiei3 ol c.tizitu dd z'tod
Page 109 and 110: ft. n€thod for rh€ dcimination
Page 111 and 112: mon dtd. pra*tu oftlz nhd %RSD 0.16
Page 113 and 114: Epsilaau c wiw t'ft^ 15100 t29\7 t6
Page 115 and 116: Ite ini.@rion reeultr of nubiprof
Page 117 and 118: Th. % availability of ednzie ra4.d
Page 119 and 120: * i t I o! I ',.! i; s is P E 3 I q
Page 121 and 122: sym€F of p€ali. The reteition t
Page 123 and 124: R.snt@ lotiurs ol.attN dA pnn4tmme
Page 125 and 126: guinfenesir dd hont€lntal weE nos
Page 127 and 128: IlF rhtive $andard &virtion of th
Page 129 and 130: It beraato., e@.s dedtutu vih qd$tl
Page 131 and 132: (ztxi@ twiiiu .lr.tiniw ad Dhpnv:|.
Page 133 and 134: Lalence [29?] developed s HPLC tech
Page 135 and 136: nbi..r.d to l! r!.llrir i! F@ (r.bt
Page 137: Trbl.3.ll2 HPLC HPLC HPI' Hptc 97.t
Page 141 and 142: 23 m t0 l5 5 t01., 97.58 lfi 55 9t.
Page 143 and 144: fi. l4itu of gliquido* d pH 9 a obs
Page 145 and 146: inding. Cctirizire sinply dbpl.c.d
Page 147 and 148: i t s .! € ! a 3 .E E E E E F g E
Page 149 and 150: The !R spccta ol nubiprofd showed c
Page 151 and 152: The deshi€ldin! efl*t ws .x.ned i
Page 153 and 154: F Synrb6ir of d..lr.tivs ol.dirlrim
Page 155 and 156: M6iqn dat updQn47U 'y1 .^"-"-r" * \
Page 157 and 158: 7,21-7.7 ppm, Pre1on for th€ CII,
Page 159 and 160: k meh Fonin !t at 3145.9? di , dipb
Page 161 and 162: Emrs ninnnbdiN .elalatiM oldtMtvt B
Page 163 and 164: €stosiblc for prcd@i!8 sup@xidc a
Page 165 and 166: T.U.3Jl *n6tttc of eniziu atd iE t
Page 167 and 168: .50 u, / i[ a r2s l{/ irl o3.12|,gr
Page 169 and 170: i o lne @F sh&te of eririziE with d
Page 171 and 172: l0 ll t2 l3 I5 l6 REFERDNCES John C
Page 173 and 174: l2 33. 34 l5 36 37 38 t9 4l 45 Bewi
Page 175 and 176: 67 63 69 70 7l 72 11 14 15 16 77 78
Page 177 and 178: 03 H.ltltm JO, Linbid LE ald CilrM
Page 179 and 180: tl9 Anyn€ Ms ed Sdr@ N (19E0) C.l
Page 181 and 182: 175 t16 t77 t78 t19 180 t8l 182 l8l
Page 183 and 184: 211. wmg D, Clcoenr P ed Smirz J 09
Page 185 and 186: 240 Ters@ H, Aliomi M ard T.tmi y (
Page 187 and 188: tumour dcs cel.coxib ohace the dti,
Page 189 and 190:
300 301 302 Shilde vM. d6ai BS .rd
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330 Baltaba UA, MaklMov Ac, ZdkiFv
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cdi;rrcdihyddhroid. (Ps)-2-12-l4l(4
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uor fron I b 9, ud rd lk Fq dutb: c
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l ni[ rh.n annilused fdr 10 nii n 1
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i.!r.IFliEdMJennd'd,4 JLD$ ftt ' 'o
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n.'tr'ddn.nq!t4-d.F ut rr!-orre@dma
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wdEldaNPlh.iffu&!nd@ry Modv.., our
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vi4l.slocl?@'fud!@e@dd'd,(D''ih)'dy
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I 56,|J'ciri's.c'.'|',vo|I.No'4.!04
Page 210 and 211:
Y* ser r.cl..,f.*,r, v"r. ro uIr.,
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Simultrnoous Dctermination of Cctir
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P49 An RP-HPIC m.lhod tor tte slnul
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Ilt 3'7i-- L:; -_I i' a \l
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Intenational Clenistry Conference R
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,/ :l i{ AB,S RACTS 7'I INTERIATIoN
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