Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

ft. $Bitivit of eftizirc &d ia (kivatiB lo s Mp'olif@tirc dd prolif.nrire 6poe
!o thc nitogo phttohem.gglutidn (PHA) &d mitogen-induccd ttulifsenio. of T-
lynph@,r6 wE w.lulr.d. Polif.Elir E po@ @ FiioglB w mailoEd at
conc.ntations of 3.12, t2.5 and 50 rgml, r, SuppFsiv. .ff*l of compoud ?14 (lcs =
4-l+0.5 |r8nl') E obs.d d T+U polifcutioa sinih.ly ?19 lhoerd cxaldt Tall
suppcaire activi9 dd it! ICs is 7.149 tgEL'' stich is duch grsLr the fi. plE l drug-
Compourd ?27 showd e int€medi.t &iivity, It exlibitcd ilhibitory aclivity (98,7 %) with
& lco l?.0 rgnl-j. Pqid 8l@ to lhc obriincd @ll3 (rlble 1.45 & fig@ 3.1lo) l*lt d
ihai the @npounds 714, 719 ed 727 d.hibitcd mtic4q &dvity ed.ould b. preved l.ad
@pourds in th.rqeudc snd and tu th studiB,
T. .1rJ3
ftrmihs dtuhhe nd ifi ttntfuttBd d.ttudh.t aW nM. uoaa fur hen intu@ nodllatks
ithibitoty popetw
r28l.r0 5741.4 169t2.1 9t.3
t390_0 10580.7 t9306,5
t2.5
121 )8788.9 2546E,9 21469.6 15.6 22.2
251t5.6 2431t_0 225t4_0 l6.t t1.7 25_4
215r9.0 24U3.7 2$tz.n 22,1 t1.6 12.5
727 r8J60.8 26244,2 93.9 15.9
122 tao95.7 29551.0 -33_4 -11.0 2.1
17266_l u!t20.6 2.s33.8 1.2
297i.1 26967,6 lJ96r,9 4.0 9.6 23.1
7tl 22285.2 25624.2 -24.5 t6l 7..1
1t2 14503.' ,0285.6 2132t.0 -23.5 I5.3 1.2
713 252t5.6 253L0 235t4,0 I5.9 I3.7 26.0
22562.1 J41t7.8 17105.5 26.4
I778.3
SD
155