Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

thtu$ro^t chnbl4 hrf,.zht!- Ruut )tiax! h crt|rj|
I/irro ttrlersction Sludi6 ofCetirizirewith Hi Re"Ptor Atrtagorkls
Nltrg SpeFoPhotomctry !id RP-HPLC
N',mSulbn, M. Stad /dvneltnd ltiDr Sbrmthld
i:l;;;i;;i ;;*;io'-d'v D'p'nn'dorPhrnderu'ci'm
Phms. UtrN.i,ry of Knd'i
rD.D, ;-' .rck."'ry. !'""i'v ,
q fi'rh o
*:C.ridzinc, $cond sd.htio HI d.ptordttsonitt, rs usl fo' rhc rratnc or'llclgn
i'dirodqs. In eh. of tlE dis4@ combincd lheEPv of III and Ir2 is lcNrallv norc
fictrdiv. tlE ii the ro'@.r orHr and H2 alone ahhoush rhG svnctsrsric cIlecr b's tol
qtien found i. all studi6 Motovct, dl.nsiw t vD stldier ha!' bd catried dur oi
!: lhe efilcLs of coadminismtion ofrhe rD tu.ptor antasooist on lhe pnamacokincr:cs
rtnd phEn&odynmics oflh. Hl tccp@r dilgonisG so i!
i"liln@h w6 adopcd 1o sludy lhe incraclion or cctiriznrc witn comnonlt admrnisteft'l
(hc p'csc'l l)a €r a r/r'
''
| tl2re.plor antagonhls ie ciniridinc, tuiridinc sd f.nordirc in simul'rinB bodv
i 'nu{s !r diflercnt pH .nd al 3?oc cing RP_HPLC and Uv sD€chpholometv An RP'
Fi. HPLC ncrhod was aho dev.loped and v'lidded for rbe sinuhmsus dcrcminrtion or
:l tnce dtuls.--r'hc nobil. phs.onsisred ofn lhlnol: w!r.r (80:20) punp€d ar, flo*
r.t. ol lmlmirll tlt€ ctuomotostam verc monilcrcd al 210 nm Th. rc$'lb tom llv
spd1tophobmclry and HPLC clc.rly i.dic.kd thal lh. availabilnv ol tclnizinc wa{
unnlfc&d bt sn.ulhncou adninislmion of H2 reeplor anlalonisl Uctrcc rc lwo
drugs euld bc aar.ly adninislorcd wirb each olher '
'X.y vor.t: Cedrizinc, IJI Kcnbr anlrgonist, lI2 rcccp(or mr|gonirr' ci'nitidinc,
tuifti.. dd [motidine, i.r.Fcrion sludics, UV spcctoPhobmclry and I II'LC
D.paiad o/