20.06.2013 Views

Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

ld.ls <strong>in</strong> vidually .ll dieb. R.sadls <strong>of</strong> brrke, eioals g.n Btty mai s<strong>in</strong> si.ble dsse<br />

mdgd€F leveb s a resull <strong>of</strong> honosblic mehmius that ightly Fgulai. rh€ absorltion<br />

and .x@tion <strong>of</strong> this meta.l. Howv€r, high.doe exposG e s6i.r,:d wirh irctted<br />

liss Mge.F l.vels, €B<strong>in</strong>g adw E@lo8i.al. ep@ducivc ad rsliElory .flal' In<br />

hmds, m&ge.s.-<strong>in</strong>d@d n.wbn€rty is dsilr€d with a mobr dys{ucrion s}nlron ,<br />

comnonly efded b d nalgdism or Pehnsonis, which b <strong>of</strong> parmout concen ed is<br />

@aid.Ed ro b. ore <strong>of</strong>rhc nolt $6itiE odpo<strong>in</strong>6 [r4]. Mdg&* is lbelb€d noD lh.<br />

smdl <strong>in</strong>resl<strong>in</strong>e and th€n F.Npolr.d via blood <strong>in</strong> rhe tival€ f@ houd lo r baa gtobut<strong>in</strong>.<br />

lraomegei!, lt h exceled <strong>in</strong> th. bil. and thro!€I the <strong>in</strong>rcat<strong>in</strong>al wall. Th€ eour.xcr.tcd<br />

<strong>in</strong> uir. is v€ty sndl [lrl4].<br />

Ircn hs the capeiry ro ecepl ed do&re €Lctrons Eadily, <strong>in</strong>t''rconverl<strong>in</strong>8 between fdri.<br />

(Fcr) od re@u (Fe'?) fom. This capabilig @la ft a Btul oopomr <strong>of</strong> cr{oheDci<br />

oxygo-b<strong>in</strong>d<strong>in</strong>g oolcule .rd nmy ozlm.s. Howr, ire. 6 ale dm!s. tissG by<br />

cslalyz<strong>in</strong>g thc convesior <strong>of</strong> hydrog€n pqoxid. io n@-udic.l ios thfi anrck elluld<br />

hmbr@s! prci.iG ud DNA. Ircn pnbpo.phydD O€be) .d ibn+ultu cluI€s sF. a<br />

@yme @feloB 0:l5l-<br />

Each crydmyte @ntaiB billioa.iohs <strong>of</strong> iren| r norml nEs <strong>of</strong><br />

tllmv{, rnis @Mntrariotr€or..pon& ro d€ iturpoErion <strong>of</strong> 2 x Ido abN <strong>of</strong> iM pdday<br />

0{61. Conseq@ntly, ddia is fie cnd<strong>in</strong>al sign <strong>of</strong> ircn d€fici.ncy. Mqr <strong>of</strong> rh€ rna<strong>in</strong><strong>in</strong>g<br />

body ircn is fould i! hepddtts sd Eticulendotb€lisl tuIophagd, which we s srodge<br />

d.poL. The livd ha firsl-ps.c.* to di€ra.y nurriols a.d @@dily tak up&mour <strong>of</strong><br />

circula<strong>in</strong>g ircn dit €xc4

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!