Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

et dt. [22E] q@rifi.d rhe sinvlsrlrin dd p,o{ihydoxysid simvslarin libehtcd ftom
sinvarad( The nethod ws chd&tdized by good liMity ovq th. n .iuM.nl rsg€ oI
Hower, i. order to d.t€mine ed qhit for the
fi$r tine efirizine in pr.s.m of stliils n€e m.thod
6 dry.lop.d and vali&led- For anlinine oFiniz.d
@ndition of lhe ncthod veious rados ol n $uol:
wrer (90:10,85:15,80:20) wre lii.rt. lt M
ob6dld lh.l i@ in lL. m.lhMl 6lio of tbe
nobile pbse r€sulled i. pmr $laniion betwd
Ju--'l
chM&sm of €in a rh.rurD,
c.lirizin. rnd aloNsralin ad incGe in tb.6tio of
Ba&I Brhcd ii tailing and lda c|cntio dnc of dogs. H.@. a rew ol84ic elrcnt m
irnoduc.d inio the sFGm. DiffeFnr nixtud of &c4loniFil., n thdol &d watd (5,E0:15,
10:70:15,20r60:lt,20:50:20,20145125, v/v/v) q@ iried. ln dl iGr.nc€s, sotr of iobil€
phas caull.d in For *?aEtid sd i! enc thc p.ar slmEy w6 disbncd-
%RSD
o.l5 10019
0.13 I00.23
0.33
o.24
0.53
0.25
101.25
t.2l 103.35
t2v/. 1.52 t04.17
Ho@, only &etonihiL: Mrq wa |an€d 4 lh. nohle pbe, lt B obefl€d thrl tt: 25
*.eroniEil.: wats gavc lhe besr Esults with pop€r *p6Fri@ of.€tirizin , aloryst tin,
61