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Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

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Th. iaitutiotr srurlr <strong>of</strong> c€rnizirc 6 Frfom.d i! prls€re <strong>of</strong> ticp<strong>of</strong>e@ &id 6<strong>in</strong>s<br />

s<strong>in</strong>ulLn@B equtioBi €psilon vdG l@ cilculded dd @ prcml.d <strong>in</strong> lable 3, t00, The<br />

irt€@tion resulls <strong>of</strong> cdir<strong>in</strong>re <strong>in</strong><br />

Fel.re <strong>of</strong> ibDprcf.n ihos thd<br />

d. Eaclion ccued !t all th. pU<br />

lw€h ed ihe % availability <strong>of</strong><br />

both thc drngs @Nid€Ebly<br />

Eprtlo, vdus d woa bSe6<br />

333<br />

16350 t 7|l2 254<br />

t0012<br />

% mihbilitr <strong>of</strong> ilru6 .r wis DH lo.l<br />

H'<br />

H?LC HPL,c HPLC<br />

100.16 t00.88 100.01 93.63 t01.69<br />

t5 l0o.3l 65.37 23t.45 lt2_14<br />

88,97 98i6 27t.ll t2t.03<br />

269.a4 l15 43<br />

I26.94 261.21 t2a 11 125_75<br />

12089 42t.66 t42.41<br />

t35.39 t22.11<br />

t05 145.78 116.78 411.88 123.7<br />

120 150.69 140.33 419.45 129.4J<br />

98..]6<br />

l5 r02.89 t06.13 93.61 \02.26<br />

120 219.77<br />

115.96 92.t5 120.46 t64.'l 106.54 96 82<br />

t2o.5a | 70ll t2E_11 192.47 I I3.43<br />

l]8.9 101.09 It9.37 82 68<br />

t30.2)<br />

r37.61 t94..33 211.87 113.44<br />

218.15 I35.43 288_12<br />

'rlE .b$rptiotr l|uim. <strong>of</strong> tuftui. &id B fould ro b. st 285@ h.e s<strong>in</strong>utr$os<br />

eqution sa usd to q@tit r€ th. rvo dnss <strong>in</strong> pEstre <strong>of</strong> @h orher (iabl€ 3.102).<br />

105

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