Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

CONCLUSTON
CaniziE is s@!d gder.rion Hr cAior d&sonisq us.d in thc leried of .wbq of
audgic disordd &d ce b€ saf€ly coldninisrored with nubd of dngs ed supplddk.
Fd {iruSiDg ald dtug-hel,l inter&tion snldi6 of etiriziE, i,ilially !s HII,C ncthods
for lhe &temiMtion in dw D.i.riak, dosa. fodularions ed in tu 9@ .LveloFd,
'nre mthods sw validai.d @rding to ICH 8!id.li6 ed pha@opoeial p.meleB
dd 1l* foud to b€ eGitiv., 6pid, Eliabl., in€xrmiv., 6y !o follow and wjdety
Thes sinullaneous nedods ll@ thcn appli.d for th. i, vr.o inle@tion snr(|i$ of Hr
Eepror dlagodn (cimetdine, 6no0dift dd tuiddirc), slati$ (arorvstati!. b$v'st ti4
rerdslain and simv.sr.rin)j quilolon€ eriber€riat agotl 0do0oei4 ofloecio,
ciprcfloeit! emeia spdfloein ed @.flo&i!), cilcim chtuel bl@keB (dilrid,
vdpuil, e odipine), non ilbitlrl erj-innallmbry druss (ris{@f.@ &i4 dictof@
$dim flurbiprcfcn, ibuprofd, m.fodh eid ed metoxim), etiDaldials
(tyrioethdir. aad cholooqui@), &rildldllj. ddss (cujfffi'a phoyt@l[ift ed
mont€luk !0, elhalosporin, (cetoisone, cephsldin arxt erohxin€) and drugs lsed ih non
iisth d.poddr digbete mclitls (e.tfodia gtib€trctMi.le dd gliqujdoe) ,!d .sgial
md tree Derals. These inrencion sludi6 werc ne.rioned on HpLC m