Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

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Simultrnoous Dctermination of Cctirizine, Diltiazc nnd Anlodipinc Using Rosvast!(in $ In tcinal Strnderd in Dosrgc l.ormohtion ,nd lhman Scflin| by RP-HPLC I lina slnpslpdr, 14. S@d AnynC atrd N.jrtr slll!tu' 't,b r, D@t*tu Eckdiitt, ud.Biry 4r,4hi xftN,752?a, Iolbb. iR.trqct td tu. ol Phdtdkaikd sdqat, D,Ntr.N {tr ,mtuid ckEhw f..'ltt 4rtu 44. udkhit otb6hi ks@^l, 75r74 Poltt@ PO-31 ir bci &Erq.d sd uiida.d for ric dddniiflii or dkr.rn. ti [$uc ordrciln.rnii.r blcr.B (di *4 rnrodipii.) Grig @4prc k idnrosnd rc *tsnrlq hdhrn 'h'r t. dc, (6ttid rrnrdror l i wi diod ws roL nd b e .nicicir ud ks c dftJ!Jrogln'|*Da@'idF'djNdsp|6'I'..mhdlidlIE I re d@t,ryr@i @r4Mn4 n. r a
ADR, imLe Pror. K C Strghal SOCIE?Y OF pt{ARMACoVtctLANCE (lNDlA} Executlv€ Comhittee (2008.09) ChletEdti.r S.cr.trry - tni.m.dor||t R.hrrbn. r,r, PDe8€ 8bB organt hca.Jnt ry Oi S:nl!ru K Tdp.tft; 1l! Yl \
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DRUG.DRUG INTERACTION STUDIES OF CE
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llfris tfr-tis is &atcf to rtJ N6rr
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S.No Dadl3 B c D E B c D E Hisory H
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E F CairiziE witb NSA.ID'3 Sinuli'e
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l0 |l l2 RESEARCII PUBLICATIONS ANT
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ABERf,VIATIONS Alnl An odipine PMA
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d ephthyldin . Th. rca.tion mh&bm f
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INTRODUCTION
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€valutcd. The nosl aDnug smup is
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wilh l@g le*iDg .ctivily. h I ob*o
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sllbiliad by inta holecurd hydrcgd
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iii High pre$we liquid chtohatogaph
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kela.@n@le withoul ihc incEbed nlk
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C Int nctilgdrug! Cetinzine is wide
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Resfuh on 4{uinolon.-3.carboxyhr€
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3 Notst@idd .ttiJnfunmto,f dr.tt (N
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dslhma swh s coughinS, whezing, dd
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Hist.oc./melabolic s}t'dmne, which
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mirlende. rh. sErion of homones ed
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e$enrid fuciion ol cob.h is rs a co
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tdd hody kd.a d.r diliihdm ir tutld
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the h@d imw sysid pDi€ct lion dip
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u CwrhaealdttutirB Whia Dlood ard e
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Raw @&ituls a.d wft of Dtmr.uticd p
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AllD( 500 MHz spetron i.r sing IMS
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T.bl.2l LMit rdgd of@lra ob.yirls B
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solutiors. Con@.nadon tug€3 of al
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3 Dmg- dru! i .ncriob srndi6 The D
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la* dd HBSS+ *s !dd.d to @h wll to
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RESULTS AND DISCUSSION The possibil
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s€@ we obs.led to b. 0.04 l!gn[ '
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povatul My of optinizing sel*dvny \
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m. xrcjD ., d. t{31 dd€lop.d d R!
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Ruggedrs ol ihc medod @ hld.!.d by
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Hce, b = lldr logth of $e ell ( I c
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nin'mM detectable linit of 5 lenl,
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The develoted nelhod M lppli.d tor
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Irr &nltri.al nsim for feotidirc .t
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tbh aS9 Ituftti@ r.s,Ls otethxiE wi
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et dt. [22E] q@rifi.d rhe sinvlsrlr
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Intudide pr*iriN of the Ntho.l % RS
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tbn ct .[dtttEadtu r=ll3!7i+0.0017
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Tr! Mid risr.l ohriBt ftr l[. Fw.dr
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l :l &rF1(,: Chudo'u.of iGdon .r Ct
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3 C.dddr. rttt qrbolon6 I Shrtt@Bd.
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Rerendon line obw.rl for ouinoton.s
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LaLt al t*tdhl nattqedtur dh lo@t6
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ft. r* ofofotuin .t pH I w fold ro
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Rcg$sion sbdnics re sboh in tablc 3
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T1E r'- of 3pd0oeir at pH I w'16I,
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M .@onim @tate. aceroniuile and l'i
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ihe ld.b of co@manon o. difrer d.F.
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.5t lt9 Itur@tt@ wltt ofqd^nN db tn
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.pfstd ttdiei3 ol c.tizitu dd z'tod
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ft. n€thod for rh€ dcimination
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mon dtd. pra*tu oftlz nhd %RSD 0.16
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Epsilaau c wiw t'ft^ 15100 t29\7 t6
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Ite ini.@rion reeultr of nubiprof
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Th. % availability of ednzie ra4.d
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* i t I o! I ',.! i; s is P E 3 I q
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sym€F of p€ali. The reteition t
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R.snt@ lotiurs ol.attN dA pnn4tmme
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guinfenesir dd hont€lntal weE nos
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IlF rhtive $andard &virtion of th
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It beraato., e@.s dedtutu vih qd$tl
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(ztxi@ twiiiu .lr.tiniw ad Dhpnv:|.
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Lalence [29?] developed s HPLC tech
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nbi..r.d to l! r!.llrir i! F@ (r.bt
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Trbl.3.ll2 HPLC HPLC HPI' Hptc 97.t
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I! th. deib.d pc.d!n, sp{rtio of il
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23 m t0 l5 5 t01., 97.58 lfi 55 9t.
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fi. l4itu of gliquido* d pH 9 a obs
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inding. Cctirizire sinply dbpl.c.d
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i t s .! € ! a 3 .E E E E E F g E
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The !R spccta ol nubiprofd showed c
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The deshi€ldin! efl*t ws .x.ned i
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F Synrb6ir of d..lr.tivs ol.dirlrim
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M6iqn dat updQn47U 'y1 .^"-"-r" * \
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7,21-7.7 ppm, Pre1on for th€ CII,
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k meh Fonin !t at 3145.9? di , dipb
Page 161 and 162: Emrs ninnnbdiN .elalatiM oldtMtvt B
Page 163 and 164: €stosiblc for prcd@i!8 sup@xidc a
Page 165 and 166: T.U.3Jl *n6tttc of eniziu atd iE t
Page 167 and 168: .50 u, / i[ a r2s l{/ irl o3.12|,gr
Page 169 and 170: i o lne @F sh&te of eririziE with d
Page 171 and 172: l0 ll t2 l3 I5 l6 REFERDNCES John C
Page 173 and 174: l2 33. 34 l5 36 37 38 t9 4l 45 Bewi
Page 175 and 176: 67 63 69 70 7l 72 11 14 15 16 77 78
Page 177 and 178: 03 H.ltltm JO, Linbid LE ald CilrM
Page 179 and 180: tl9 Anyn€ Ms ed Sdr@ N (19E0) C.l
Page 181 and 182: 175 t16 t77 t78 t19 180 t8l 182 l8l
Page 183 and 184: 211. wmg D, Clcoenr P ed Smirz J 09
Page 185 and 186: 240 Ters@ H, Aliomi M ard T.tmi y (
Page 187 and 188: tumour dcs cel.coxib ohace the dti,
Page 189 and 190: 300 301 302 Shilde vM. d6ai BS .rd
Page 191 and 192: 330 Baltaba UA, MaklMov Ac, ZdkiFv
Page 193 and 194: cdi;rrcdihyddhroid. (Ps)-2-12-l4l(4
Page 195 and 196: uor fron I b 9, ud rd lk Fq dutb: c
Page 197 and 198: l ni[ rh.n annilused fdr 10 nii n 1
Page 199 and 200: i.!r.IFliEdMJennd'd,4 JLD$ ftt ' 'o
Page 201 and 202: n.'tr'ddn.nq!t4-d.F ut rr!-orre@dma
Page 203 and 204: wdEldaNPlh.iffu&!nd@ry Modv.., our
Page 206 and 207: vi4l.slocl?@'fud!@e@dd'd,(D''ih)'dy
Page 208 and 209: I 56,|J'ciri's.c'.'|',vo|I.No'4.!04
Page 210 and 211: Y* ser r.cl..,f.*,r, v"r. ro uIr.,
Page 214 and 215: P49 An RP-HPIC m.lhod tor tte slnul
Page 216 and 217: Ilt 3'7i-- L:; -_I i' a \l
Page 218 and 219: Intenational Clenistry Conference R
Page 220 and 221: ,/ :l i{ AB,S RACTS 7'I INTERIATIoN
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Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

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