Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

Resfuh on 4{uinolon.-3.carboxyhr€s had l.d to th€ dieovery of a fmily of 6-flum-7,
pip€ruinyl4-quinolon s &live aeainst bur.ti. i, ytuo s well s ui!@lluld palhosqs ed
t inethoFin eisl' micrebes tEa9al. Coudrivcly. rh* @Dpouds \,ft called
fdoquinoloes [E51. 'fte quinoloft adbet!.ials e p|lE to l@y inr.Ecriotu vith other
&!gs. Quinoloft .beDlion b nEledly Edw.d wnh mrtri& and rh.r.p.uric failw my
resull. OilM nelallic ion-contaiong drugs 6.ls r€dwe abso+rion. Som. ofue newer
quinolones inlibned tbe ct1@hrcne P450 systen.
T.bL l,r
Qukot B &kd.dJor tiktdiLr I7+1n
(phs d min6|+fl mF2Jnihydrc3-m€$yl-l014n.rlyl.!pipq@inyt>7oxo-7
H- pyrido{ l:,3- de l- l,4,b.naEin.-6-
€lb.r)lic,c'd:( rHrfNo. aprle)elto\orbnShr ' . _
t.llow, cryshlline poNder, slightly soluble in wdr€r,
glioirl reric ei4 slighlly solubl. mdhylere chlolid.
ItttlopDpyl+nlre l,1.diht de{{xc 7{ | tip.e'nt l) 3{urnon*
catorylic eid; C'HdNIO I Solubl. in *e.
ifilil,fr"lt**""'""'cubreisrn'
l-.lhyl-6-fl uorc-1.4-dihydc4-oxo-7-(l-pipsrinylll,&naghlh yridirc-3-
@boxylio eidj CTHDFNaOT, il foms cry$ls
in dhsovnetiyleF chlori(|q tr nelring poirn
is 220-224"C.
(cir!5-minGl4rclop'qyu{l,tnindhyll-pip.djnyll6,8iillrcl,4dihyde-4{xc3-quimli'@!6oxylic
ci4
CFHlFrNlOr, Y€llow n .dl6 iom 95%
rl6hol, melling poii 263!C , lolubl. in
!lk!li.s, hot alcohal, pEoric.lty iMluble in
I -.thyl-6.fl uorl,4-dihydD-.4{x67{ lpiFEzinyl}3-quinolinobox ylic
&i4 C6Htr FN: Or, molcult *.ighr irll9.l,
A Bhit q palcyellow. hyg@pic,
phd@.sniv., cry$llic po*d.r, v..t sliehdy
slubl. in tur, slighly s.lubl. in dm and
l9