Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

Thc intmctlon rcsuh oI c€tinzinc
in pFs€M of diclof.N $dim
cldly indic.Ld thd @tion
@oE!d al sll rhc pH la€k. Il
w obswed that rvailability of
diclofcu. $dih (@id€obly deElsed i! pt*re of etirizire. TIE iolc6.rioD Mg€
obercd for didof@ $diu .r.il dE bufld n diu tug.d b.r@ 26,2&56.1070 on
Uv -lisible spectrophotomelq, sinild rend was obsw€d on HPLC, which w6 5o.EE-
7E.45% I! lhc s. my, tbc itr&cdon Bults for c€tniziF .i .ll pH lcrcb wE ir lh.
tu9. of 157.13- | 61.94% d uv-visiblc sp.ctrqhorom.&r &d E0,45-2t 0,03% on HPLC.
T.bL 3,!,
Epiton wtt6 d wio6 b,I.B
D
t5100 9237
16850 l0l7l I t57
pHo 16350 10t35 9804 .l l7
HPLC HPI' HPLC
IM lod.t2 t0().t5
It 67.95 93.91 96.91 9!.86
l0 72.59 26.62 8?.88 4.1.0J 37.52
65.92 24.20 35.24 t3.69 88.i8
5524 54.U 20.62 n.1a 54.29 91.54
75 5E.77 Itol 16_t5
53.00 t4|l 1068 3l7l
t2.17 681 5t.61
120 t0.88 2626 69.89
|l0.t3 95.3) 9n.18 93.1|
r5 35
16986 8.t.]6 87.35 31.19
130.24 r85.51 46.12 88.5J lIl.36 31.72
|l5.]6 |1.66 37.t9
I5 t70.92 187,2t |r1_t t25.83 3713
90 170.31 192.\4 10.08 t29.27 34.33
l0t l98.ll 5.33 81.16 3t.69
r20 2ro.0l t2n.76 5t.tt
ftc MimM .r.lyticd sign l ob@ed for flubipreIer w !r 246 m ir all pH bedi@.
H.M limiramB .qu.rio! B lppli.d to. th. q@riialion of I[* drugs in
l0l