Improved Methodology for the Preparation of Chiral Amines

2.2.2. Different Substrates Categories 36
2.2.3. Nguyen Special Substrates 39
2.3. Asymmetric Reduction of N-aryl imines 40
2.3.1. Synthesis of N-Aryl Imines 40
2.3.2. Different Substrates Categories 43
2.4. Reduction of Miscellaneous Imines 49
2.5 Conclusion 49
2.6. References 50
3. Reductive Amination
3.1. Historical View 53
3.1.1. Reductive Amination Utilizing Heterogeneous Catalyst 53
3.1.2. Reductive Amination Utilizing Homogenous Catalysis 55
3.2. Reductive Amination the Current State of Art 57
3.3. Asymmetric Reductive Amination 60
3.3.1. Asymmetric Reductive Amination Utilizing Chiral Catalysts 60
3.3.2. Reductive Amination Utilizing Chiral Auxiliary 64
3.3.3. Reductive Amination Utilizing Molecular Hydrogen 65
3.3.4. Asymmetric Reductive Amination Utilizing Transfer
Hydrogenation Conditions 66
3.4.5. Organocatalytic Asymmetric Reductive Amination 67
3.4. Green Chemistry and Reductive Amination 73
3.4.1. Green Chemistry Basic principle 73
3.4.2. Hydrogenation and Green Chemistry 75
3.5. Conclusion 76
3.6. References 76
4. Drugs and Reductive Amination
4.1 Reductive Amination in the Synthesis of Drugs and Natural Products 81
4.1.1. Synthesis of Delavirdine 81
4.1.2. Synthesis of Muraglitazar 82
4.1.3. Synthesis of Amphetamine 83
4.1.4. Synthesis of Sertraline 84
ix