Improved Methodology for the Preparation of Chiral Amines

Figure 2.4 General Catalyst structures:
+
R
PH
N
O
BARF -
P
Fe
P
Ir
[{Ir(cod)Cl} 2 ]
R
Catalyst 2
R= H
Catalyst 1
R
OCH 3
R
R
R
O
P
O
R
O
R
O O
P
O
O
O O
R
R
Ir
Ph 2 P
O PPh 2 O
O
O O
Ph t P
OCH
2 BuSiO
3
O
O
OSi t BuPh O
2
P
H 3 CO
[Ir(COD) 2 ]BF 4
R= t Bu
Catalyst 3
OCH 3
Catalyst 4
S
R 2
R 2
P
Ir
N
O
R 1
BARF
*
P
=
P
R
R
P
P
DuPHOS
R
R
RuCl 2
NH 3
* =
NH 3
H Ph
2 N
H 2 N Ph
DPEN
R 1 = i Pr, R 2 =Ph
Catalyst 5
*
P
P
Cl
Ru
Cl
H 2 N
H 2 N
*
Catalyst 6
Ph 2
P
Ir
O
CF 3 SO -
+
O
BARF -
N
N Ir
P
Ph 2
Ph
N
Ph
P
Ir
N
O
H
R
+
BARF -
(S,R)-15 or (S,S)-15
Catalyst 841
R= i Pr
Catalyst 9
Catalyst 7