Improved Methodology for the Preparation of Chiral Amines

Figure 2.1: General Substrates Categories.
N P(O)Ph 2
N P(O)Ph 2
N P(O)Ph 2
1
2
R
3
Figure 2.2: General Catalysts Categories.
H 3 C H
PR 2
Fe PR 2
O
t-Bu
OMe
josiphos type
[Rh(nbd) 2 ]BF 4
(R)-(S)-R 2 PF-PR 2
R = cycohexyl, t Bu 2
Catalyst 1
O
N N
Co
O O
Catalyst 2
O
O
O
O
P
P
t-Bu
CuCl
t-Bu
2
t-Bu
OMe
2
(R)-(-)-DTBM-SEGPHOS
Ph
Ph
N
Ir
N
H 2
Catalyst 4
Cl
Ph
Ph
N
Rh
N
H 2
Catalyst 5
Cl
NC
Catalyst 3
R
O
N
O Cl
Re
N Cl
O
OPPh 3
R
R= 4- t Bu-ph
Ph
Ph
O
Catalyst 6
Ph
N N
H H
ZnEt 2
Catalyst 7
Ph
O PPh 2
O PPh 2
O
Pd(CF 3 CO 2 ) 2
L-5 (S)-SEGPHOS
Catalyst 8
S
S
n
NH HN
n=2
ZnEt 2
Catalyst 9
S
n
S
2.2.2. Different Substrates Categories.
Phenyl alkyl N-phosphinoyl imines (Structure 1, 2, 3, figure 2.1) have been extensively
investigated over the last few years. We will focus our investigation on the results for the last
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