II International Symposium on Carbon for Catalysis ABSTRACTS

PP-<strong>II</strong>-1
FUNCTIONALIZATION OF CARBON NANO BALL FOR BIO-MEDICAL
APPLICATIONS
Abdi S.H.R., Liu Zhen-Xue, Park Yong-Ki, Park Seung-Kyu 1 , Lee Chul Wee
Advanced Chemical Technology Division, Korea Research Institute of Chemical Technology,
Daejeon 305-600, Korea
1 LG Household & Health Care Research Park, Daejeon 305-343, Korea
e-mail : chulwee@krict.re.kr
Carbon nano balls (CNBs) are basically hollow core mesoporous shell structures with specific
surface area of 1,230m 2 /g and the total pore volume 1.27 cm 3 /g as determined by nitrogen
BET adsorption measurements [1,2] have attracted much attention for potential applications
in many fields of science and engineering [3]. Drawing parallel with carbon nano tubes
(CNTs) it would be interesting to investigate the utility of CNBs for its application as carrier
for drug delivery [4]. The task of drug delivery can be accomplished by means of either
physical adsorption of the drug onto CNB or by chemical modification of CNB i.e., through
functionalization [5]. The later has been found to be better in terms of better controlled release
of the drug than former where the release of the drug can be fast and uncontrolled.
In this report we disclose the functionalization of CNBs by oxidation route and its
modification with 1-docosanol, a known antiviral long chain alcohol [6]. In a simple synthetic
step the CNBs were oxidized with dilute sulfuric acid nitric acid mixture at 80 o C for 18 h for
generation of carboxyl groups on the surface of CNBs. The oxidized material was treated with
thionyl chloride followed by its interaction with 1-docosanol for its chemical linkage with
CNBs through ester linkage (Scheme-1). The oxidized material and 1-docosanol supported
CNB (CNB-1D) were characterized by elemental analysis, 1 H and 13 C NMR, XPS and SEM
analysis. The biological activity of the CNB-1D is in progress and would be communicated in
due course.
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