N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
Result : TS concentration % sensitization sensitizing potential
0.05 % TS 50 % medium
0.5 % TS 90 % very high
controls 0 % -
-Clinical signs: not reported
The authors also noted a cross-sensitization to
N-phenyl-N'-cyclohexyl-p-phenylenediamine (CPPD): 30 % of animals
sensitized to 6PPD showed cross-sensitization to 0.05 % CPPD in
vaseline. Animals sensitized to p-phenylenediamine (PPD) or to N-
isopropyl-N'-phenyl-p-phenylenediamine showed also cross-sensitization to
6PPD (see table).
Table: Cross-Sensitization in guinea pigs (% animals cross-sensitized)
Cross-reaction product tested (0.05 % in vaseline):
Sensitizer: CPPD 6PPD PPD IPPD
CPPD 50 5 15 nd
6PPD 30 50 nd nd
PPD 100 95 80 95
IPPD 90 85 100 10
Test condition : TEST ANIMALS:
-Strain: Hartley albino
-Sex: female
-Weight at study initiation: 400 g
-Number of animals: 20
-Controls: yes
ADMINISTRATION/EXPOSURE:
-Preparation of test substance for induction: in olive oil
and petrolatum
-Concentrations used for induction: 0.5 % in olive oil with
complete FCA, one week later 1 % in petrolatum
-Concentrations used for challenge: 0.05 and 0.5 % in
petrolatum
-Positive control: p-phenylenediamine
EXAMINATIONS:
-Grading system: Magnusson & Kligman
Reliability : (2) valid with restrictions
Study meets generally accepted scientific principles,
without detailed documentation, acceptable for assessment
Flag : Critical study for SIDS endpoint
04.06.2004 (62)
Type : Patch-Test
Species : human
Number of animals :
Vehicle : petrolatum
Result :
Classification :
Method : other
Year : 1996
GLP : no data
Test substance : no data
Result : 5/9 contact dermatitis patients showed a positive reaction
to TS;
cross-sensitization also to
N-isopropyl-N'-phenyl-p-phenylenediamine, p-phenylenediamine
100
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