N-(1,3-Dimethylbutyl)-N
N-(1,3-Dimethylbutyl)-N
N-(1,3-Dimethylbutyl)-N
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OECD SIDS<br />
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE<br />
5. TOXICITY ID: 793-24-8<br />
DATE: 11.05.2005<br />
CLINICAL SIGNS:<br />
loss of appetite, lethargy, gradual wasting at >= 5010 mg/kg<br />
NECROPSY FINDINGS:<br />
liver discoloration, pulmonary hyperemia<br />
Test condition : ADMINISTRATION:<br />
-Occlusion: plastic strips<br />
-Vehicle: none<br />
-Doses: 798, 1260, 2000, 3160, 5010, 7980 mg/kg<br />
-Removal of test substance: no data<br />
EXAMINATIONS:<br />
clinical symptoms; autopsy of viscera<br />
Reliability : (2) valid with restrictions<br />
Study meets generally accepted scientific principles,<br />
data from summary without detailed documentation, acceptable<br />
for assessment<br />
Flag : Critical study for SIDS endpoint<br />
04.10.2001 (56)<br />
5.1.4 ACUTE TOXICITY, OTHER ROUTES<br />
5.2.1 SKIN IRRITATION<br />
Species : rabbit<br />
Concentration : undiluted<br />
Exposure : Occlusive<br />
Exposure time : 24 hour(s)<br />
Number of animals : 3<br />
Vehicle :<br />
PDII :<br />
Result : slightly irritating<br />
Classification :<br />
Method : Draize Test<br />
Year : 1962<br />
GLP : no data<br />
Test substance : no data<br />
Result : AVERAGE SCORE:<br />
0, 0.6, 1.6, 1.3, 1.0, 0<br />
REVERSIBILITY:<br />
starting at 48 h, totally reversible at 120 h<br />
Test condition : TEST ANIMALS:<br />
-Strain: albino<br />
-Sex: no data<br />
-Number of animals: 3<br />
ADMINISTRATION/EXPOSURE<br />
-Preparation of test substance: undiluted<br />
-Area of exposure: not reported<br />
-Occlusion: plastic strips<br />
-Vehicle: none<br />
-Postexposure period: 120 hrs<br />
-Removal of test substance: soap and water<br />
EXAMINATIONS<br />
-Scoring system: Draize<br />
UNEP PUBLICATIONS 95
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