N-(1,3-Dimethylbutyl)-N
N-(1,3-Dimethylbutyl)-N
N-(1,3-Dimethylbutyl)-N
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OECD SIDS<br />
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE<br />
5. TOXICITY ID: 793-24-8<br />
DATE: 11.05.2005<br />
0.99 0.181<br />
solvent control 0.266<br />
positive control 1.123<br />
No significantly increased number of transformed foci for TS<br />
(t-test)<br />
Test condition : TOXICITY SCREENING:<br />
-Concentrations: 15 concentrations from 0.061 - 1000 µg/ml<br />
-Solvent: DMSO<br />
-Negative controls: only medium, 0.5 % DMSO<br />
-Exposure: 24 h<br />
-Post-exposure incubation: 5-7 days<br />
-Dose selection: highest concentration with reduction in<br />
colony forming ability of less than 90 %<br />
CELL TRANSFORMATION ASSAY:<br />
-Concentrations: 0.165, 0.33, 0.495, 0.66, 0.99 µg/ml<br />
-Solvent: DMSO<br />
-Negative controls: only medium, 0.5 % DMSO<br />
-Positive control: 3-methylcholanthrene<br />
-Replicates: 20 dishes/concentration<br />
-Exposure: 24 h<br />
-Post-exposure incubation: 4 w<br />
Reliability : (2) valid with restrictions<br />
Test procedure in accordance with generally accepted<br />
scientific principles and described in sufficient detail<br />
Flag : Critical study for SIDS endpoint<br />
11.06.2003 (101)<br />
5.8.1 TOXICITY TO FERTILITY<br />
Type : other: Reproduction toxicity screening test<br />
Species : rat<br />
Sex : male/female<br />
Strain : Crj: CD(SD)<br />
Route of admin. : gavage<br />
Exposure period : males: 48 d; females: 14 d before mating until day 3 of lactation<br />
Frequency of treatm. : once daily<br />
Premating exposure period<br />
Male :<br />
Female : 14 d<br />
Duration of test : males: 48 d; females: until day 4 of lactation<br />
No. of generation :<br />
studies<br />
Doses : 0; 6; 25; 100 mg/kg bw/d<br />
Control group : yes, concurrent vehicle<br />
NOAEL parental : = 100 mg/kg bw<br />
NOAEL F1 offspring : = 100 mg/kg bw<br />
Result : With regard to reproductive toxicity, no adverse effects were observed in<br />
terms of the estrous cycle, copulation and fertility results or findings for<br />
delivery.<br />
Method : other: see ME<br />
Year : 2001<br />
GLP : yes<br />
Test substance : other TS<br />
Method : Reproduction/developmental toxicity screening test according to OECD TG<br />
421<br />
Remark : The detailed description of this study can be found in chapter 5.4<br />
Result : The test substance had no effect on body weight gain. Food consumption<br />
130<br />
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