N-(1,3-Dimethylbutyl)-N
N-(1,3-Dimethylbutyl)-N
N-(1,3-Dimethylbutyl)-N
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OECD SIDS<br />
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE<br />
5. TOXICITY ID: 793-24-8<br />
DATE: 11.05.2005<br />
Reliability : (4) not assignable<br />
Documentation insufficient for assessment<br />
Only results were given<br />
28.08.2001 (88)<br />
Type : Ames test<br />
System of testing : Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537<br />
Test concentration : µg/plate: TA1535, TA1537/-S9mix: up to 19.5; TA98, 100/-S9mix: up to<br />
78.1; TA100, TA1535, TA1537/+S9mix: up to 156; TA98/+S9mix: up to<br />
625 (details see TC)<br />
Cycotoxic concentr. : µg/plate: TA1535, TA1537/-S9mix: 9.77-19.5; TA98, 100/-S9mix: 39.1;<br />
TA100, TA1535/+S9mix: 156; TA1537/+S9mix: 78.1; TA98/+S9mix: 625<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: OECD Guide-line 471, Guidelines for Screening Toxicity Testings of<br />
Chemicals (Japan)<br />
Year : 1999<br />
GLP : yes<br />
Test substance : other TS: 99 % purity<br />
Remark : The positive control chemicals (sodium azide, 2-aminoanthracene, 9-<br />
aminoacridine, 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide) led to the expected<br />
increase in revertants.<br />
Test condition : SYSTEM OF TESTING<br />
- Metabolic activation system:<br />
rat liver, induced with phenobarbital and 5,6-benzoflavon<br />
ADMINISTRATION:<br />
- Dosing:<br />
strain metabolic concentration:<br />
µg/plate<br />
activation<br />
TA1535, TA1537 -S9 mix 0, 0.61, 1.22, 2.44, 4.88, 9.77, 19.5<br />
TA98, TA100 -S9 mix 0, 2.44, 4.88, 9.77, 19.5, 49.1, 78.1<br />
TA100, TA1535, TA1537 +S9 mix 0, 4.88, 9.77, 19.5, 39.1, 78.1, 156<br />
TA98 +S9 mix 0, 19.5, 39,1, 78.1, 156, 313, 625<br />
- Number of replicates: 2; plates/test: 3<br />
- Application: Pre-incubation method<br />
- Positive and negative control groups and treatment:<br />
negative control: solvent DMSO<br />
positive controls: -S9mix:<br />
2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide (TA98, TA100);<br />
sodium azide (TA1535); 9-aminoacridine (TA1537);<br />
+S9mix: 2-aminoanthracene<br />
- Pre-incubation time: not specified in summary<br />
Reliability : (1) valid without restriction<br />
Guideline study; original reference in Japanese, compilation<br />
of data from English summary and tables<br />
Flag : Critical study for SIDS endpoint<br />
11.08.2003 (59) (96)<br />
Type : Bacterial reverse mutation assay<br />
System of testing : Escherichia coli WP2 uvrA<br />
Test concentration : 313, 625, 1250, 2500, 5000 µg/plate<br />
Cycotoxic concentr. : > 5000 µg/plate<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: Guidelines for Screening Toxicity Testings of Chemicals (Japan)<br />
Year : 1999<br />
UNEP PUBLICATIONS 121
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