N-(1,3-Dimethylbutyl)-N

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OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 4. ECOTOXICITY ID: 793-24-8 DATE: 11.05.2005 were confirmed by NMR, IR and HPLC. Kept at room temperature in a dark place until use. Conclusion : (Based on measured concentration) · EiC50 (24-hour, mortality or immobility): 0.40 mg/l · EiC50 (48-hour, mortality or immobility): 0.23 mg/l · NOECi (48-hour, mortality or immobility): 0.05 mg/l Reliability : (1) valid without restriction Experimental design and analytical procedure were well documented Flag : Critical study for SIDS endpoint 08.11.2004 (46) Type : Static Species : Daphnia magna (Crustacea) Exposure period : 48 hour(s) Unit : mg/l NOEC : = .25 LC50 : = .51 Analytical monitoring : No Method : other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates and Amphibians (US-EPA 1975) Year : 1984 GLP : No Test substance : other TS: Santoflex 13 and degradation products Method : static bioassay; parallel experiments (I) with freshly spiked medium and (II) after aging for 24h Result : The following results were obtained depending on the ageing of the test medium (nominal 6PPD concentrations) 0 h aging 48 h NOEC 0.25 mg/l LC50 0.51 mg/l 24 h aging 48 h NOEC > 1 mg/l 0 h aging refers to tests with freshly prepared medium. When the test solution was allowed to age 24 h before test, 1.0 mg/l (= solubility limit, highest tested concentration) had no effect on survival Test condition : - Stock solution in acetone (max. 1 ml/l) - Daphnias were fed a suspension of Purina trout chow and alfalfa daily until 24 h prior to testing - Daphnias less than 24 h old were used for assay - Assay conducted in 250 ml glass beakers containing 200 ml well water (= dilution water) from St. Peters, Missouri - Each beaker contained 10 Daphnias; 3 replicates - Dilution water (well water): pH 7.6 - 8.3, oxygen 6.4 - 8.6 mg/l, hardness 210 - 290 mg/l, alkalinity 218 - 274 mg/l. The well water contained some heavy metals (e.g. Fe 0.013 mg/l, Cu 0.005 mg/l, Mo 0.005 mg/l, V 0.14 mg/l, Zn 0.006 mg/i) - Incubation at 22 °C - Lighting regime: 16 h daylight, 8 h night - Endpoint immobilization Test substance : Santoflex 13 and transformation products were tested. Transformation products were obtained by aging 6PPD solutions. For aging 6PPD solution was prepared in aerobic well water and stirred for 24 h at room temperature (22 °C). The well water was slightly basic and contained some heavy metal ions (e.g. Fe 0.013 mg/l, Cu 0.005 mg/l, Mo 0.005 mg/l, V 0.14 mg/l, Zn 0.006 mg/i). Reliability : (2) valid with restrictions Study in accordance with generally accepted scientific standards and described in sufficient detail Flag : Critical study for SIDS endpoint 08.08.2003 (50) Type : Static Species : Daphnia magna (Crustacea) 84 UNEP PUBLICATIONS
OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 4. ECOTOXICITY ID: 793-24-8 DATE: 11.05.2005 Exposure period : 48 hour(s) Unit : mg/l NOEC : = .56 LC50 : = .82 Analytical monitoring : No Method : other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates and Amphibians (US-EPA 1975) Year : 1978 GLP : No Test substance : other TS: Santoflex 13 Method : static bioassay Remark : Test substance concentration not monitored during exposure; due to the instability of the TS in aqueous solution, the effective TS concentrations may be significantly different from the applied nominal concentrations Result : 24 h LC50 = 1.0 (0.79 - 1.3) mg/l 48 h LC50 = 0.82 (0.71 - 0.94) mg/l 48 h NOEC = 0.56 mg/l Test condition : - Stock solution 25 mg/l 6PPD in acetone - Daphnias were fed a suspension of trout chow and alfalfa daily until 24 h prior to testing - Instar less than 18 h old were used for assay - Assay conducted in 500 ml glass beakers containing 250 ml well water (= dilution water), 10 Daphnias each, 7 replicates - Dilution water: pH 7.7, oxygen 8.7 mg/l, hardness < 250 mg/l, alkalinity < 250 mg/l - Incubation at 19 +/- 1 °C, - Lighting regime: 16 h daylight, 8 h night - At end of exposure pH 8.4; dissolved oxygen 7.4 mg/l - Endpoint mortality Test substance : Santoflex 13 is described as dull purple solid Reliability : (2) valid with restrictions Study in accordance with generally accepted scientific standards and described in sufficient detail Flag : Critical study for SIDS endpoint 03.08.2003 (51) Type : Static Species : Daphnia magna (Crustacea) Exposure period : 48 hour(s) Unit : mg/l NOEC : = .4 EC50 : = .79 Analytical monitoring : No Method : OECD Guide-line 202 Year : 1984 GLP : no data Test substance : other TS: Santoflex 13 Remark : C.I. for EC50 = 0.7 - 0.91 mg/l 24 hr EC50=1.6 mg/l 48 hr EC50=0.79 mg/l in presence of food 48 hr EC50 = 1.3 mg/l and NOEC=0.4 mg/l Test condition : - Daphnias were fed a suspension of trout chow and alfalfa daily until 24 h prior to testing - Instar less than 18 h old were used for assay - Assay conducted in 500 ml glass beakers containing 250 ml well water (= dilution water), 10 Daphnias each, 7 replicates - Dilution water: pH 7.7, oxygen 8.7 mg/l, hardness < 250 mg/l, alkalinity < UNEP PUBLICATIONS 85
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N-(1,3-Dimethylbutyl)-N

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