N-(1,3-Dimethylbutyl)-N

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OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 793-24-8 DATE: 11.05.2005 t1/2 pH9 : at °C Degradation : 88 - 96 % after 22 hour(s) at pH and 24 °C Deg. product : Method : other: River die-away in Mississippi River water Year : 1981 GLP : Yes Test substance : other TS: Santoflex 13 Remark : pH of sterile Mississippi River water not reported (in the Results section for T1/2 assumed to be pH = 7) Result : 96 % primary degradation in sterile river water in 22 h 88 % primary degradation in deionized water in 22 h Rate of disappearance of 6PPD in active and sterile Mississippi River water and in deionized water are listed respectively as follows (% remainder of 1 mg/l initial concentration): Hour Water active sterile deionized 0 hour 100 % 100 % 100 % 1 hour 60 % 85 % 100 % 2 hour 43 % 70 % 88 % 3 hour 33 % 56 % 86 % 4 hour 38 % 49 % 80 % 5 hour 26 % 41 % 65 % 22 hour 3 % 4 % 12 % The half life periods were calculated to be 2.9 h in active river water, 3.9 h in sterile river water and 6.8 h in sterile deionized water. Reliability : (2) valid with restrictions Study well documented, meets generally accepted scientific principles, acceptable for assessment Flag : Critical study for SIDS endpoint 03.11.2004 (37) Type : Abiotic t1/2 pH4 : at °C t1/2 pH7 : at °C t1/2 pH9 : at °C t1/2 pH 2 : > 28 day(s) at 4 °C Deg. product : Method : other: see Method Year : 1992 GLP : no data Test substance : other TS: 6PPD, analysis grade Method : Study to examine migration from rubber articles. - Solid phase column extraction (stationary phase RP-18 silcagel; column preconditioning with methanol and NaOH; elution with CH2Cl2, filled up with acetonitrile) - Analysed by HPLC/UV Remark : Although several parts of the study are described in detail, the stability tests were onlsy breifly mentioned and information on exposure conditions is sparse Result : 6PPD is stable for at least 4 weeks in aqueous solutions at pH 2 in the cold, but will be degraded at neutral or basic pH within a few hours. Reliability : (4) not assignable Documentation insufficient for assessment Flag : Critical study for SIDS endpoint 03.11.2004 (38) Type : Abiotic t1/2 pH4 : at °C t1/2 pH7 : 5 hour(s) at 50 °C 62 UNEP PUBLICATIONS
OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 793-24-8 DATE: 11.05.2005 t1/2 pH9 : at °C t1/2 pH 7 : 8 - 14 hour(s) at 26 °C Deg. product : Yes Method : other: similar to OECD 111 Year : 2003 GLP : No Test substance : other TS: 6PPD, purity > 98 % Deg. products : 122-37-2 204-538-9 4-anilinophenol Method : Study design similar to OECD Guideline 111 but environmental parameters modified to facilitate interpretation of ecotox studies. Radiation, redox (aerobic instead of anaerobic), and nutrient medium conditions simulated those used in ecotoxicological tests. Test 1: Kinetics of primary degradation and major transformation product studied in the light at 50 °C in buffer pH 7 Test 2: Kinetics of primary degradation and major transformation product studied in the light at 26 °C in buffer pH 7 Test 3: Kinetics of primary degradation and major transformation product studied in the light at 26 °C in algae nutrient solution In both tests analytical monitoring of test substance and main metabolite (4-hydroxydiphenylamine) using HPLC with UV detection Result : 6PPD degradation in aerobic solutions is dependent on the temperature and on heavy metals. In aerobic buffer at 50 °C the half life of 6PPD is about 5 h, which is increased to about 14 h at 26 °C. In algae medium the half life period was significantly decreased to 8 h at the same temperature. 4-Hydroxydiphenylamine was identified as the major aromatic intermediate of 6PPD degradation under all conditions. Test 1 buffer solution pH 7, 50 °C Half life periods of 6PPD 5 h Maximum formation of 4-Hydroxy-diphenylamine 54 %* Test 2 buffer solution pH 7, 26 °C Half life periods of 6PPD 14 h Maximum formation of 4-Hydroxy-diphenylamine 99 %* Test 3 nutrient medium pH 7, 26 °C Half life periods of 6PPD 8 h Maximum formation of 4-Hydroxy-diphenylamine 75 %* * maximum concentration of 4-hydroxydiphenylamine divided by initial concentration of 6PPD Test condition : All tests were done under the following conditions: - The Erlenmeyer flask was irradiated with a lamp at 8000 lux. - All solutions were at pH 7 and air saturated Test 1: 50 °C, buffer medium Test 2: 26 °C, buffer medium Test 3: 26 °C, algae nutrient medium The buffer medium was sodiumdihydrogen phosphate 0.1 mol/l, adjusted to pH 7 with NaOH. The algae nutrient medium was adjusted to pH 7 and passed through a sterile filter before use: Concentration in test solution [mg/L]: NaHCO3 50 NH4Cl 15 MgCl2 x 6H2O 12 CaCl2 x 2H2O 18 MgSO4 x 7H2O 15 KH2PO4 1.6 FeCl3 x 6H2O 0.08 Na2EDTA x 2H2O 0.1 UNEP PUBLICATIONS 63
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N-(1,3-Dimethylbutyl)-N

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