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N-(1,3-Dimethylbutyl)-N

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OECD SIDS<br />

N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE<br />

5. TOXICITY ID: 793-24-8<br />

DATE: 11.05.2005<br />

Year : 1976<br />

GLP : no data<br />

Test substance : no data<br />

Reliability : (4) not assignable<br />

Cited from BUA report no 208 (1996)<br />

No further information available<br />

28.08.2001 (90)<br />

Type : Cytogenetic assay<br />

System of testing : Chinese hamster ovary cells (CHO)<br />

Test concentration : no data<br />

Cycotoxic concentr. : no data<br />

Metabolic activation : no data<br />

Result : negative<br />

Method : other<br />

Year : 1987<br />

GLP : no data<br />

Test substance : no data<br />

Reliability : (4) not assignable<br />

Documentation insufficient for assessment<br />

Only results were given<br />

28.08.2001 (91)<br />

Type : Cytogenetic assay<br />

System of testing : Chinese hamster ovary cells (CHO)<br />

Test concentration : up to 15 ug/ml<br />

Cycotoxic concentr. : no data<br />

Metabolic activation : with and without<br />

Result :<br />

Method : other<br />

Year : 1987<br />

GLP : no data<br />

Test substance : no data<br />

Result : without S-9 mix: negative<br />

with S-9 mix: Increased aberration rates were occasionally<br />

induced at 5-15 ug/ml (preparatory times of 6-24 hrs).<br />

However, these effects were not concentration-dependent and<br />

were always linked to drastic cytotoxicity, so that the<br />

overall result was equivocal.<br />

Reliability : (4) not assignable<br />

Cited from BUA report no 208 (1996)<br />

No further information available<br />

28.08.2001 (92)<br />

Type : Mouse lymphoma assay<br />

System of testing : L5178Y TK mouse lymphoma cells<br />

Test concentration : up to 4 ug/ml (without S-9 mix); up to 33 ug/ml (with S-9 mix)<br />

Cycotoxic concentr. : no data<br />

Metabolic activation : with and without<br />

Result : negative<br />

Method : other<br />

Year : 1976<br />

GLP : no data<br />

Test substance : no data<br />

Reliability : (4) not assignable<br />

Cited from BUA report no 208 (1996)<br />

UNEP PUBLICATIONS 119

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