N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
5.0 TOXICOKINETICS, METABOLISM AND DISTRIBUTION
5.1.1 ACUTE ORAL TOXICITY
Type : LD50
Value : = 3340 mg/kg bw
Species : rat
Strain : Sprague-Dawley
Sex : male/female
Number of animals : 5
Vehicle :
Doses : 2510, 3160, 3980, 5010 mg/kg bw
Method : other
Year : 1962
GLP : no data
Test substance : no data
Result : MORTALITY:
-Time of death: 2-5 d p.a.
-Number of deaths at each dose: 1/5, 2/5, 3/5, 5/5 at 2510,
3160, 3980, 5010 mg/kg
-LD50: 3340 mg/kg (limits: 2890-3875 mg/kg)
CLINICAL SIGNS:
collapse in 15-30 min p.a. application following recovery
after several h in some cases; severe diarrhea, loss of
appetite, salivation, dyspnea
NECROPSY FINDINGS:
inflammation of gastric mucosa, renal and liver congestion
POTENTIAL TARGET ORGANS:
not reported
SEX-SPECIFIC DIFFERENCES:
not reported
Test condition : ADMINISTRATION:
-Doses: 2510, 3160, 3980, 5010 mg/kg
-Doses per time period: single dose
-Volume administered or concentration: feeding of undiluted
test substance by stomach tube
-Post dose observation period: no data
EXAMINATIONS:
clinical symptoms, autopsy of viscera
Reliability : (2) valid with restrictions
Study meets generally accepted scientific principles,
data from summary without detailed documentation, acceptable
for assessment
Flag : Critical study for SIDS endpoint
04.10.2001 (56)
Type : LD50
Value : = 3580 mg/kg bw
Species : rat
Strain : Sprague-Dawley
Sex : male/female
90
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