N-(1,3-Dimethylbutyl)-N

More documents

Recommendations

Info

OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 4. ECOTOXICITY ID: 793-24-8 DATE: 11.05.2005 contained less than 0.05 mg/l total NH3. On page 8 of the study it is reported that the controls contained between 0.8-1.8 mg/l "Ammonia" and Santoflex 13 incubation solutions contained between 0.6-3.2 mg/l "Ammonia". On page 6 of the study it is stated that "the ammonia concentrations were below the toxic level" and a 592 pages study is cited without giving additional information on how the conclusion was drawn. Even if "total NH3" including NH4 is meant on page 8, the concentration is too high and might have led to reactions above a treshold due to additional ammonia released from the degrading test substance. According to OECD Guideline 305 (flow through fish test for bioconcentration measurement) and 210 (fish early live stage) dilution water is only acceptable as long as the unionised ammonia concentration is below 1 µg/l. Since the pKa (ammonium) is approximately 9.25, the unionised ammonia concentration exceeded 1 µg/l at physiological pH. According to the following equation, free ammonia exceeded the acceptable concentration of these guidelines by 1-2 orders of magnitude: % unionised ammonia of total ammonia = 100 / (1 + antilog (pKa -pH)) [pKa = 0.09018 + 2729.92 /Temperature in Kelvin]. - Although it was anounced by the authors that the acetone concentrations are reported in appendix 1 of the study, no acetone concentrations could be found. - It is not explained by the authors why the controls contained approximately half of the 6PPD concentration of the lowest tested 6PPD concentration - Limit(s) of detection/quantification not clearly reported Result : Day of exposure/nominal LC50 [mg/l] (estimated concentration [mg/l] derived from measured values as far as available) for endpoint mortality 2/2 3/0.48 4/0.45 (0.26) 5/0.41 6-8/0.35 9-10/0.32 11-13/0.30 14/0.27 15/0.24 16/0.21 17/0.20 18/0.18 19-21/0.17 22-25/0.16 26-28/0.15 The authors concluded that the lethal threshold had not been reached after 28 days. They also stated that Santoflex 13 appeared to have cumulative toxicity. Test condition : Test fish: Obtained from Fender's Fish Hatchery, Brady, Nebraska; acclimated for at least 14 days prior to testing; fed with standard commercial fish food (Rangen's) in amounts of 3 % of their body weight; mean weight 1.3 g; mean standard length 40.1 mm; qualitiy check with Antimycin A, done prior to test, revealed fish were in good condition; selection for test by random assignment, 30 fishs/aquarium Summary on concentrations of test substance (mg/l): nominal measured (mean) 0.066 0.024 0.12 0.034 0.23 0.089 0.45 0.26 1.0 0.92 Concentrations of test substance in detail (mg/l): 78 UNEP PUBLICATIONS
OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 4. ECOTOXICITY ID: 793-24-8 DATE: 11.05.2005 Control Day Measured concentration 0 < 0.01 1 < 0.01 5 < 0.01 10 < 0.01 14 < 0.01 21 0.022 28 0.020 Mean 0.013 Nominal 0.066 mg/l Day Measured concentration 0 0.029 1 < 0.01 5 0.042 10 0.015 14 0.024 21 0.022 28 0.025 Mean 0.024 Nominal 0.12 mg/l Day Measured concentration 0 0.054 1 0.01 5 0.031 10 0.035 14 0.033 21 0.046 28 0.027 Mean 0.034 Nominal 0.23 mg/l Day Measured concentration 0 0.109 1 0.042 5 0.058 10 0.095 14 0.122 21 0.136 28 0.063 Mean 0.089 Nominal 0.45 mg/l Day Measured concentration 0 0.316 1 0.158 5 0.217 10 0.271 14 0.266 21 0.354 28 0.232 Mean 0.26 Nominal 1.0 mg/l Day Measured concentration 0 1.33 1 0.705 5 0.951 10 0.815 UNEP PUBLICATIONS 79
Page 1 and 2:
OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28: OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´
Page 77: OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143:
show all

N-(1,3-Dimethylbutyl)-N

Create successful ePaper yourself

Delete template?

Save as template?