N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
-Examination time points: 1, 4, 24, 48, 72, 120 hrs
Reliability : (2) valid with restrictions
Study meets generally accepted scientific principles,
data from summary without detailed documentation, acceptable
for assessment
Flag : Critical study for SIDS endpoint
04.10.2001 (56)
Species : rabbit
Concentration : .5 other: ml (undiluted)
Exposure : no data
Exposure time :
Number of animals : 6
Vehicle :
PDII :
Result : slightly irritating
Classification :
Method : Draize Test
Year : 1977
GLP : no data
Test substance : no data
Result : Primary cutaneous irritation index:
0.6 for 2.5 % TS; classified as low irritant potential
1.0 for 25 % TS; classified as low irritant potential
REVERSIBILITY:
yes
OTHER EFFECTS:
no skin necrosis
Test condition : TEST ANIMALS:
-Strain: New Zealand
-Sex: female
-Weight at study initiation: 2.4-2.7 kg
-Number of animals: 6
ADMINISTRATION/EXPOSURE
-Area of exposure: no data
-Occlusion: no data
-Vehicle: vaseline
-Concentration in vehicle: 2.5 and 25 %
-Application to scarified and unscarified skin
-Postexposure period: 72 h
-Removal of test substance: no data
EXAMINATIONS
-Scoring system: erythema, edema accoding to Draize;
calculation of primary cutaneous irritation index
-Examination time points: 24 and 72 hours
Reliability : (2) valid with restrictions
Study meets generally accepted scientific principles,
without detailed documentation, acceptable for assessment
Flag : Critical study for SIDS endpoint
04.10.2001 (62)
Species : rabbit
Concentration : .5 other: ml (undiluted)
Exposure : Semiocclusive
Exposure time : 24 hour(s)
96
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