N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
increase in micronuclei rate.
Test condition : TEST ORGANISMS:
-No. of animals per dose: 5
ADMINISTRATION:
-Vehicle: suspension in 1 % gum accacia
-Duration of test: termination 24 h after second application
-Frequency of treatment: two doses within 24 hours
-Sampling times and number of samples: 24 h after second
application
-Control groups and treatment: negative control: 1 % gum
accacia; positive control: 100 mg cyclophosphamide/kg bw
-Criteria for selection of doses: > 200 mg/kg bw were found
to be lethal
Reliability : (2) valid with restrictions
Study well documented, meets generally accepted scientific
principles, acceptable for assessment
Flag : Critical study for SIDS endpoint
11.06.2003 (99)
5.7 CARCINOGENICITY
Species : rat
Sex : male/female
Strain : other: Charles River CD
Route of admin. : oral feed
Exposure period : 24 months
Frequency of treatm. : continuously in diet
Post exposure period : no
Doses : 0, 100, 300 or 1000 ppm
Result : negative
Control group : yes, concurrent no treatment
Method : other
Year :
GLP : no data
Test substance : no data
Remark : 0, 100, 300 or 1000 ppm = ca. 0, 8, 23 or 75 mg/kg bw/d
Result : Survival rate (in %) was comparable with controls:
0 100 300 1000 ppm
males 24 28 26 28
females 56 52 46 52
>= 100 ppm: no changes in organ weights, no gross or
microscopic tissue changes;
1000 ppm: reduced body weight gain (with decreased food
consumption during the first week of the study); decrease in
erythrocyte counts, hemoglobin concentration and hematocrit
values at some interim intervals, but not at the end of the
study. Increased kidney and spleen weights at terminal
sacrifice only in females.
Histopathologic Observations:
Average number of lesions per animal
Control / 100 ppm / 300 ppm / 1000 ppm
Males:
Number examined / 19 / 15 / 18 / 25
UNEP PUBLICATIONS 127