N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
Type : Sub-chronic
Species : rat
Sex : male/female
Strain : Sprague-Dawley
Route of admin. : oral feed
Exposure period : 13 weeks
Frequency of treatm. : continuously in diet
Post exposure period : no
Doses : 0, 250, 1000 or 2500 ppm
Control group : yes
NOAEL : = 250 ppm
LOAEL : = 1000 ppm
Method : other
Year : 1987
GLP : yes
Test substance : other TS: Santoflex 13 (purity 97.1%)
Result : ACTUAL DOSE RECEIVED BY DOSE LEVEL BY SEX:
-males: 15.7, 62.3, 153.8 mg/kg bw/d
-females: 18.5, 75.0, 172.1 mg/kg bw/d
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL:
-Mortality and time to death: none
-Clinical signs: no treatment related effects
-Body weight gain: males from 1000 ppm and females at 2500
ppm: reduced rate of weight gain from start of exposure;
significantly reduced body weight from end of second study
week till study end; NOAEL 250 ppm
Table: Terminal Body Weights in g (% of control)
Group Control 250 ppm 1000 ppm 2500 ppm
Males 429.1 (100)/ 415.2 (97)/ 392.6 (92)/ 371.8 (87)
Females 264.0 (100)/ 260.3 (99)/ 248.2 (94)/ 238.5 (90)
-Food consumption: from 1000 ppm: greatly reduced in first
study week, thereafter consistently below controls for males from 1000
ppm and females at 2500 ppm
Table: Food consumption in g/day (% of control)
Group Control 250 ppm 1000 ppm 2500 ppm
Males 25.6 (100)/ 24.6 (96)/ 23.3 (91)/ 22.0 (86)
Females 19.0 (100)/ 18.9 (99)/ 18.3 (96)/ 16.2 (85)
-Ophthalmoscopic examination: no treatment related effects
-Clinical chemistry: from 1000 ppm: increase of total
protein, albumin, globulin, calcium, cholesterol; decrease
of SGOT, SGPT, creatinine, BUN; only in males: bilirubin
elevated
-Haematology: from 1000 ppm: mild anemia: mild decrease of
RBC, Hb, MCV, HCT, MCH, MCHC; thrombocytosis (study end);
females from 250 ppm: decrease of WBC and lymphocytes; slight anemia
in interim sampling period only
-Organ weights:
Table: Absolute organ weights (g)
Organ /Sex / Control/ 250 ppm/ 1000 ppm/ 2500 ppm
Brain/ male/ 2.090/ 2.134/ 2.086/ 2.073
Brain/ female/ 1.953/ 1.973/ 1.955/ 1.953
Kidneys/ male/ 3.354/ 3.391/ 3.387/ 3.329
Kidneys/ female/ 2.005/ 2.074/ 2.106/ 2.097
Liver/ male/ 15.263/ 15.347/ 16.873/ 17.942**
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