N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
Method : other
Year : 1970
GLP : no data
Test substance : other TS: technical preparation of Santoflex 13
Result : no death, body weight gain within the normal range,
increased oxygen consumption, suppression of the central
nervous system and of the synthezising function of the liver
(content of hippuric acid in a 24 h urine sample was
decreased), decreased ascorbic acid content in the liver
Reliability : (3) invalid
Documentation insufficient for assessment
30.08.2001 (58)
Type : Sub-acute
Species : rat
Sex : male/female
Strain : Sprague-Dawley
Route of admin. : gavage
Exposure period : 28 days
Frequency of treatm. : not specified
Post exposure period : 14 days
Doses : 0, 4, 20, 100 mg/kg bw/d
Control group : yes, concurrent vehicle
NOAEL : = 20 mg/kg bw
LOAEL : = 100 mg/kg bw
Method : other: see ME
Year : 1999
GLP : yes
Test substance : other TS: 99 % purity
Method : Guidelines for 28-Day Repeat Dose Toxicity Testing of
Chemicals (Japan)
Remark : The authors derived a NOEL of 4 mg/kg bw for this study
(Ohara et al., 1999).
As a sex-specific sensitivity is obvious from the study data
the NOEL of 4 mg/kg bw is only valid for the female rats.
The effects observed at the LOEL of 20 mg/kg bw were of a
rather mild nature (reversible periportal fatty change of
the liver without an increase of liver weight; increased
total serum protein). In contrast, there were adverse
effects on a range of different parameters observed at 100
mg/kg for both sexes so that the LOAEL for both sexes is
rather at the dose of 100 mg/kg bw and the NOAEL at 20 mg/kg
bw.
Result : TOXIC RESPONSE/EFFECTS BY DOSE LEVEL:
-Mortality and time to death: none
-Clinical signs: not reported
-Body weight gain: no effect
-Food consumption: not reported
-Clinical chemistry:
20 mg/kg: females: at end of administration sig. increase of
total protein
(p