N-(1,3-Dimethylbutyl)-N

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OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 5. TOXICITY ID: 793-24-8 DATE: 11.05.2005 Method : other Year : 1983 GLP : no data Test substance : other TS: technical grade Result : I.) ED50 (dose/egg) 1.5 umol maximum malformed: 40 % II.) dose/egg (umol) affected embryos (early/late deaths, malformations) in % 0.55 0 (n=10) 1.1 20 (n=30) 2.2 43 (n=30) 4.4 33 (n=30) Test condition : TS was tested for embryotoxicity and induction of malformations in three-day chicken embryos Reliability : (3) invalid Unsuitable test system 14.10.2001 (106) (107) 5.8.3 TOXICITY TO REPRODUCTION, OTHER STUDIES 5.9 SPECIFIC INVESTIGATIONS 5.10 EXPOSURE EXPERIENCE Remark : Biomonitoring Result : In the rubber industry 6PPD was detected in the urine of 6PPD exposed workers. In environmental air levels were in the range of < 0.01 - 260 ug/mc (peak 6600) and in urine levels were in the range of < 1 - 300 ug/g creatinine (peak 580). The samples were collected between 1982 and 1987. Reliability : (2) valid with restrictions Test procedure in accordance with generally accepted scientific principles and described in sufficient detail Flag : Critical study for SIDS endpoint 04.10.2001 (108) Remark : Monitoring The authors desribed analytical methods for the determination of the trace levels of 6PPD in human urine. In the publication of Pavan et. al. (1987) the abbreviation 6PPD is used however the substance is called N-(2,3-dimethylpropyl)-N-phenyl-1,4-benzenediamine with the CAS-No. 739-24-8. Result : analytical methods for the determination of the trace levels 30.08.2001 (109) (110) 04.10.2001 136 UNEP PUBLICATIONS
OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 5. TOXICITY ID: 793-24-8 DATE: 11.05.2005 5.11 ADDITIONAL REMARKS Type : other Remark : A comprehensive description of the toxicity profile is available in the BUA-Report No. 208 (1996) 29.08.2001 UNEP PUBLICATIONS 137
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N-(1,3-Dimethylbutyl)-N

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