N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
-Number of animals: 6
ADMINISTRATION/EXPOSURE
-Area of exposure: no data
-Occlusion: no data
-Vehicle: olive oil
-Concentration in vehicle: 1 g/20 ml
-Application to scarified and unscarified skin
-Postexposure period: 72 h
-Removal of test substance: no data
EXAMINATIONS
-Scoring system: erythema, edema accoding to Draize;
calculation of primary cutaneous irritation index
-Examination time points: 24 and 72 hours
Reliability : (2) valid with restrictions
Study meets generally accepted scientific principles,
without detailed documentation, acceptable for assessment
Flag : Critical study for SIDS endpoint
04.10.2001 (62)
5.2.2 EYE IRRITATION
Species : rabbit
Concentration : undiluted
Dose : .1 ml
Exposure time : 24 hour(s)
Comment :
Number of animals : 3
Vehicle :
Result : slightly irritating
Classification :
Method : Draize Test
Year : 1962
GLP : no data
Test substance : no data
Method : 0.1 ml was placed into the conjunctival sac of the right eye
of each of 3 rabbits (24 h exposure), then eyes rinsed with
warm isotonic saline solution. Observation period 5 days.
Result : AVERAGE SCORE:
20.6/110
REVERSIBILITY:
within 5 d
Test condition : TEST ANIMALS:
-Strain: albino
-Sex: no data
DESCRIPTION OF LESIONS:
After 1 hour slight edema and erythema, copious discharge,
and slight dullness of the corneal area. Iris and cornea
cleared somewhat in 24 h, within 72 h iris clarity normal
ADMINISTRATION/EXPOSURE:
-Vehicle: none
-Postexposure period: 120 h
98
EXAMINATIONS:
-Scoring system: Draize
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