N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
Result : 9/10 volunteers, who had reacted to previous rubber samples,
reacted positive.
Reliability : (2) valid with restrictions
Study well documented, meets generally accepted scientific
principles, acceptable for assessment
Flag : Critical study for SIDS endpoint
03.06.2004 (74)
Type : other: see TC
Species : guinea pig
Number of animals : 45
Vehicle : no data
Result : not sensitizing
Classification :
Method : other
Year : 1970
GLP : no data
Test substance : other TS: Santoflex 13
Result : no sensitizing reaction of test animals
Test condition : Daily application of a 50 % paste over 20 days onto the
clipped skin of the back. For the challenge different
concentrations (10, 20, 30, 50 and 100 %) were applied to
new areas of the back (no further data available).
Reliability : (4) not assignable
Documentation insufficient for assessment
07.10.2001 (58)
5.4 REPEATED DOSE TOXICITY
Type : Sub-acute
Species : rat
Sex : male/female
Strain : Sprague-Dawley
Route of admin. : inhalation
Exposure period : 4 weeks
Frequency of treatm. : 6 h/d and 5d/w
Post exposure period : no data
Doses : 54, 236 or 477 mg/m3
Control group : no data specified
NOAEL : = 54 mg/m³
LOAEL : = 236 mg/m³
Method : other
Year :
GLP : no data
Test substance : no data
Result : >= 236 mg/m3: increased activity of alanine aminotransferase
in serum, decreased glucose levels and increased relative
liver weights in males;
477 mg/m3: reduction of average corpuscular hemoglobin
levels in males
At necropsy no treatment related gross lesions were noted.
Reliability : (4) not assignable
Cited from BUA report no 208 (1996)
No further information available
04.06.2004 (75)
UNEP PUBLICATIONS 105