N-(1,3-Dimethylbutyl)-N

More documents

Recommendations

Info

OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 5. TOXICITY ID: 793-24-8 DATE: 11.05.2005 5.0 TOXICOKINETICS, METABOLISM AND DISTRIBUTION 5.1.1 ACUTE ORAL TOXICITY Type : LD50 Value : = 3340 mg/kg bw Species : rat Strain : Sprague-Dawley Sex : male/female Number of animals : 5 Vehicle : Doses : 2510, 3160, 3980, 5010 mg/kg bw Method : other Year : 1962 GLP : no data Test substance : no data Result : MORTALITY: -Time of death: 2-5 d p.a. -Number of deaths at each dose: 1/5, 2/5, 3/5, 5/5 at 2510, 3160, 3980, 5010 mg/kg -LD50: 3340 mg/kg (limits: 2890-3875 mg/kg) CLINICAL SIGNS: collapse in 15-30 min p.a. application following recovery after several h in some cases; severe diarrhea, loss of appetite, salivation, dyspnea NECROPSY FINDINGS: inflammation of gastric mucosa, renal and liver congestion POTENTIAL TARGET ORGANS: not reported SEX-SPECIFIC DIFFERENCES: not reported Test condition : ADMINISTRATION: -Doses: 2510, 3160, 3980, 5010 mg/kg -Doses per time period: single dose -Volume administered or concentration: feeding of undiluted test substance by stomach tube -Post dose observation period: no data EXAMINATIONS: clinical symptoms, autopsy of viscera Reliability : (2) valid with restrictions Study meets generally accepted scientific principles, data from summary without detailed documentation, acceptable for assessment Flag : Critical study for SIDS endpoint 04.10.2001 (56) Type : LD50 Value : = 3580 mg/kg bw Species : rat Strain : Sprague-Dawley Sex : male/female 90 UNEP PUBLICATIONS
OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 5. TOXICITY ID: 793-24-8 DATE: 11.05.2005 Number of animals : 5 Vehicle : no data Doses : Method : other Year : 1973 GLP : no data Test substance : other TS: purity 95.7 % Result : MORTALITY: -Time of death: not reported -Number of deaths at each dose: 1/5, 2/5, 3/5, 3/5, 4/5 CLINICAL SIGNS: reduced appetite and activity (lasting for 2-5 days), increasing weakness, diarrhea, ocular discharge, collapse NECROPSY FINDINGS: hemorrhagic lungs; liver discoloration (jaundice), acute gastrointestinal inflammation LD50: 95 % confidence limit 3400-3760 mg/kg Test condition : ADMINISTRATION: -Doses: 2510, 3160, 3980, 5010, 6310 mg/kg -Post dose observation period: 12 d EXAMINATIONS: Clinical symptoms, autopsy; Calculation of LD50 according to method of de Beer Reliability : (2) valid with restrictions Study meets generally accepted scientific principles, data from summary without detailed documentation, acceptable for assessment Flag : Critical study for SIDS endpoint 04.10.2001 (57) Type : LD50 Value : = 2500 mg/kg bw Species : rat Strain : other: white rats Sex : no data Number of animals : Vehicle : other: sunflower oil Doses : Method : other Year : 1970 GLP : no data Test substance : other TS: technical preparation of Santoflex 13 Result : TS showed marked narcotic action, death occurred from day 1-3 after application Reliability : (3) invalid Documentation insufficient for assessment 30.08.2001 (58) Type : LD50 Value : = 1005 mg/kg bw Species : rat Strain : Sprague-Dawley Sex : male Number of animals : 5 Vehicle : other: corn oil UNEP PUBLICATIONS 91
Page 1 and 2:
OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40: OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´
Page 89: OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´
Page 141 and 142:
Page 143:
show all

N-(1,3-Dimethylbutyl)-N

Create successful ePaper yourself

Delete template?

Save as template?