N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
Doses : 0, 250, 500, 1000, 2000 mg/kg bw
Method : OECD Guide-line 401 "Acute Oral Toxicity"
Year : 1999
GLP : yes
Test substance : other TS: purity 99 %
Result : LD50: 1005 mg/kg (95% confidence limit: 711-1604 mg/kg)
MORTALITY:
-Time of death: day 2-4 p.a.
-Number of deaths at each dose: 0/5, 0/5, 0/5, 2/5, 5/5
CLINICAL SIGNS:
from 500 mg/kg: reduced volume of feces;
from 1000 mg/kg: hypoactivity, diarrhea, bradypnea,
hypothermia, prone position;
2000 mg/kg: abnormal gait
NECROPSY FINDINGS:
pathological lesions in digestive organs and respiratory
system
POTENTIAL TARGET ORGANS:
not reported
SEX-SPECIFIC DIFFERENCES:
male rats were less sensitive than female rats
Test condition : ADMINISTRATION:
-Doses: 0, 250, 500, 1000, 2000 mg/kg
-Doses per time period: single dose via gavage
-Volume administered or concentration: no data
-Post dose observation period: 8-15 d
EXAMINATIONS: clinical symptoms, necropsy
Reliability : (1) valid without restriction
Guideline study; original reference in Japanese, compilation
of data from English summary and tables
Flag : Critical study for SIDS endpoint
11.05.2005 (59) (60)
Type : LD50
Value : = 893 mg/kg bw
Species : rat
Strain : Sprague-Dawley
Sex : female
Number of animals : 5
Vehicle : other: corn oil
Doses : 0, 250, 500, 1000, 2000 mg/kg bw
Method : OECD Guide-line 401 "Acute Oral Toxicity"
Year : 1999
GLP : yes
Test substance : other TS: purity 99 %
Result : LD50: 893 mg/kg (95% confidence limit: 634-1346 mg/kg)
MORTALITY:
-Time of death: day 2-4 p.a.
-Number of deaths at each dose: 0/5, 0/5, 0/5, 3/5, 5/5
CLINICAL SIGNS:
from 500 mg/kg: reduced volume of feces;
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