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N-(1,3-Dimethylbutyl)-N

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OECD SIDS<br />

N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE<br />

5. TOXICITY ID: 793-24-8<br />

DATE: 11.05.2005<br />

Number of animals : 6<br />

Vehicle :<br />

PDII :<br />

Result : not irritating<br />

Classification :<br />

Method : other<br />

Year : 1973<br />

GLP : no data<br />

Test substance : other TS: purity 95.7 %<br />

Result : AVERAGE SCORE<br />

0.0/8.0<br />

Test condition : TEST ANIMALS:<br />

-Strain: New Zealand albino<br />

-Sex: Male/female<br />

-Number of animals: 6<br />

ADMINISTRATION/EXPOSURE<br />

-Preparation of test substance: undiluted<br />

-Area of exposure: no data<br />

-Occlusion: semiocclusive<br />

-Postexposure period: 7 d<br />

-Removal of test substance: after 24 hours<br />

EXAMINATIONS<br />

-Scoring system: Federal Hazardous Substance Act 21 CFR, §<br />

191.11 (1964)<br />

-Examination time points: no data<br />

Reliability : (2) valid with restrictions<br />

Study meets generally accepted scientific principles,<br />

data from summary without detailed documentation, acceptable<br />

for assessment<br />

Flag : Critical study for SIDS endpoint<br />

04.10.2001 (57)<br />

Species : rabbit<br />

Concentration : .5 other: mg (undiluted)<br />

Exposure : no data<br />

Exposure time :<br />

Number of animals : 6<br />

Vehicle :<br />

PDII : 3.3<br />

Result : moderately irritating<br />

Classification :<br />

Method : Draize Test<br />

Year : 1977<br />

GLP : no data<br />

Test substance : no data<br />

Result : Primary cutaneous irritation index:<br />

3.3; classified as medium irritant potential<br />

REVERSIBILITY:<br />

yes<br />

OTHER EFFECTS:<br />

no skin necrosis<br />

Test condition : TEST ANIMALS:<br />

-Strain: New Zealand<br />

-Sex: female<br />

-Weight at study initiation: 2.4-2.7 kg<br />

UNEP PUBLICATIONS 97

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