N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
from 1000 mg/kg: hypoactivity, diarrhea, bradypnea,
hypothermia, prone position;
2000 mg/kg: lacrimation, weakness of limbs
NECROPSY FINDINGS:
pathological lesions in digestive organs and respiratory
system
POTENTIAL TARGET ORGANS:
not reported
SEX-SPECIFIC DIFFERENCES:
female rats were more sensitive than male rats
Test condition : ADMINISTRATION:
-Doses: 0, 250, 500, 1000, 2000 mg/kg
-Doses per time period: single dose via gavage
-Volume administered or concentration: no data
-Post dose observation period: 8-15 d
EXAMINATIONS: clinical symptoms, necropsy
Reliability : (1) valid without restriction
Guideline study; original reference in Japanese, compilation
of data from English summary and tables
Flag : Critical study for SIDS endpoint
11.05.2005 (59) (60)
Type : LD50
Value : = 3200 mg/kg bw
Species : mouse
Strain : other: white mice
Sex : no data
Number of animals :
Vehicle : other: sunflower oil
Doses :
Method : other
Year : 1970
GLP : no data
Test substance : other TS: technical preparation
Result : TS showed marked narcotic action, death occurred from day
1-3 after application
Reliability : (3) invalid
Documentation insufficient for assessment
27.08.2001 (58)
Type : LD50
Value : = 1120 mg/kg bw
Species : other: no data
Strain : no data
Sex : no data
Number of animals :
Vehicle : no data
Doses :
Method : other
Year : 1973
GLP : no
Test substance : no data
Reliability : (4) not assignable
Cited from data sheet
No further information available
UNEP PUBLICATIONS 93