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N-(1,3-Dimethylbutyl)-N

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OECD SIDS<br />

N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE<br />

5. TOXICITY ID: 793-24-8<br />

DATE: 11.05.2005<br />

Method :<br />

Year : 1972<br />

GLP :<br />

Test substance : other TS: 0.1 % W/V solution in dimethylphthalate<br />

Result : 0/50 volunteers reacted positive<br />

Reliability : (2) valid with restrictions<br />

Study well documented, meets generally accepted scientific<br />

principles, acceptable for assessment<br />

Flag : Critical study for SIDS endpoint<br />

03.06.2004 (68)<br />

Type : other: Repeated Insult Patch Test<br />

Species : human<br />

Number of animals :<br />

Vehicle : no data<br />

Result :<br />

Classification :<br />

Method :<br />

Year : 1964<br />

GLP :<br />

Test substance : other TS: I.) 2 parts 6-PPD per hundred parts rubber (unvulcanized); II.) 2<br />

parts 6-PPD per hundred parts rubber (vulcanized)<br />

Result : I.) 0/50 human subjects not previously exposed to test<br />

rubber formulations reacted positive.<br />

II.) 0/50 human subjects not previously exposed to test<br />

rubber formulations reacted positive.<br />

Reliability : (2) valid with restrictions<br />

Study well documented, meets generally accepted scientific<br />

principles, acceptable for assessment<br />

Flag : Critical study for SIDS endpoint<br />

03.06.2004 (69)<br />

Type : other: Repeated Insult Patch Test<br />

Species : human<br />

Number of animals :<br />

Vehicle : no data<br />

Result :<br />

Classification :<br />

Method :<br />

Year :<br />

GLP :<br />

Test substance : no data<br />

Result : 4/50 subjects reacted positive:<br />

2: 1+<br />

1: 2+<br />

1: 3+<br />

Reliability : (2) valid with restrictions<br />

Study well documented, meets generally accepted scientific<br />

principles, acceptable for assessment<br />

Flag : Critical study for SIDS endpoint<br />

03.06.2004 (70)<br />

Type : other: Repeated Insult Patch Test<br />

Species : human<br />

Number of animals :<br />

Vehicle : other: dimethylphthalate<br />

Result :<br />

Classification :<br />

UNEP PUBLICATIONS 103

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