N-(1,3-Dimethylbutyl)-N

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OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 5. TOXICITY ID: 793-24-8 DATE: 11.05.2005 Type : Sub-chronic Species : rat Sex : male/female Strain : Sprague-Dawley Route of admin. : oral feed Exposure period : 13 weeks Frequency of treatm. : continuously in diet Post exposure period : no Doses : 0, 250, 1000 or 2500 ppm Control group : yes NOAEL : = 250 ppm LOAEL : = 1000 ppm Method : other Year : 1987 GLP : yes Test substance : other TS: Santoflex 13 (purity 97.1%) Result : ACTUAL DOSE RECEIVED BY DOSE LEVEL BY SEX: -males: 15.7, 62.3, 153.8 mg/kg bw/d -females: 18.5, 75.0, 172.1 mg/kg bw/d TOXIC RESPONSE/EFFECTS BY DOSE LEVEL: -Mortality and time to death: none -Clinical signs: no treatment related effects -Body weight gain: males from 1000 ppm and females at 2500 ppm: reduced rate of weight gain from start of exposure; significantly reduced body weight from end of second study week till study end; NOAEL 250 ppm Table: Terminal Body Weights in g (% of control) Group Control 250 ppm 1000 ppm 2500 ppm Males 429.1 (100)/ 415.2 (97)/ 392.6 (92)/ 371.8 (87) Females 264.0 (100)/ 260.3 (99)/ 248.2 (94)/ 238.5 (90) -Food consumption: from 1000 ppm: greatly reduced in first study week, thereafter consistently below controls for males from 1000 ppm and females at 2500 ppm Table: Food consumption in g/day (% of control) Group Control 250 ppm 1000 ppm 2500 ppm Males 25.6 (100)/ 24.6 (96)/ 23.3 (91)/ 22.0 (86) Females 19.0 (100)/ 18.9 (99)/ 18.3 (96)/ 16.2 (85) -Ophthalmoscopic examination: no treatment related effects -Clinical chemistry: from 1000 ppm: increase of total protein, albumin, globulin, calcium, cholesterol; decrease of SGOT, SGPT, creatinine, BUN; only in males: bilirubin elevated -Haematology: from 1000 ppm: mild anemia: mild decrease of RBC, Hb, MCV, HCT, MCH, MCHC; thrombocytosis (study end); females from 250 ppm: decrease of WBC and lymphocytes; slight anemia in interim sampling period only -Organ weights: Table: Absolute organ weights (g) Organ /Sex / Control/ 250 ppm/ 1000 ppm/ 2500 ppm Brain/ male/ 2.090/ 2.134/ 2.086/ 2.073 Brain/ female/ 1.953/ 1.973/ 1.955/ 1.953 Kidneys/ male/ 3.354/ 3.391/ 3.387/ 3.329 Kidneys/ female/ 2.005/ 2.074/ 2.106/ 2.097 Liver/ male/ 15.263/ 15.347/ 16.873/ 17.942** 106 UNEP PUBLICATIONS
OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 5. TOXICITY ID: 793-24-8 DATE: 11.05.2005 Liver/ female/ 8.370/ 9.262/ 9.577*/ 10.485** Spleen/ male/ 0.779/ 0.759/ 0.736/ 0.748 Spleen/ female/ 0.596/ 0.594/ 0.581/ 0.472** Testes/ male/ 5.634/ 5.459/ 5.290/ 5.058* *) significantly different from control (
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N-(1,3-Dimethylbutyl)-N

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