N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
and p-aminoazobenzene
Test condition : 9 farmers with contact allergy due to rubber boots were
patch-tested with rubber additives
occlusive patch-test using Finn chambers for 48 hours;
concentration 0.1 % in pet.; readings after 30 min and 24
hours after removal of the patch according to ICDRG criteria
Reliability : (1) valid without restriction
Test procedure in accordance with generally accepted
scientific principles and described in sufficient detail
Flag : Critical study for SIDS endpoint
03.06.2004 (63)
Type : Patch-Test
Species : human
Number of animals :
Vehicle : no data
Result :
Classification :
Method :
Year : 1997
GLP :
Test substance : no data
Result : Compilation of data from 135 patients patch-tested with
rubber additives.
6/135 contact dermatitis patients showed a positive
reaction to 6PPD; partly with cross-sensitizations (23 of 28 patients
sensitized to IPPD showed also positive reactions to 6PPD).
Reliability : (2) valid with restrictions
Data from handbook or collection of data
Flag : Critical study for SIDS endpoint
03.06.2004 (64)
Type : Patch-Test
Species : human
Number of animals :
Vehicle : other: lanolin
Result :
Classification :
Method :
Year : 1977
GLP :
Test substance : no data
Remark : 15/15 IPPD-allergic patients were tested positive in the
test with 6-PPD (concentration 2 % in lanolin; readings taken during the
48th hour)
Reliability : (2) valid with restrictions
Study well documented, meets generally accepted scientific
principles, acceptable for assessment
Flag : Critical study for SIDS endpoint
03.06.2004 (62)
Type : Patch-Test
Species : human
Number of animals :
Vehicle : no data
Result :
Classification :
Method :
Year : 1963
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