N-(1,3-Dimethylbutyl)-N

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OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 5. TOXICITY ID: 793-24-8 DATE: 11.05.2005 protein (p
OECD SIDS N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE 5. TOXICITY ID: 793-24-8 DATE: 11.05.2005 adrenal glands, testes, epididymides, ovaries of 5 rats per sex from control and dose groups at end of administration and 5 rats per sex from control and high dose group at end of recovery period -Macroscopical examination: 5 rats per sex from control and dose groups at end of administration and 5 rats per sex from control and high dose group at end of recovery period -Microscopic: 5 rats per sex from control and dose groups at end of administration and 5 rats per sex from control and high dose group at end of recovery period Reliability : (1) valid without restriction Guideline study; original reference in Japanese, compilation of data from English summary and tables Flag : Critical study for SIDS endpoint 11.08.2003 (59) (80) Type : Sub-acute Species : rat Sex : male/female Strain : Crj: CD(SD) Route of admin. : gavage Exposure period : Males: 48 d; Females: 14 d before mating until day 3 of lactation Frequency of treatm. : once daily Post exposure period : no Doses : 0; 6; 25; 100 mg/kg bw/d Control group : yes, concurrent vehicle NOAEL : = 6 mg/kg bw LOAEL : = 25 mg/kg bw Method : other: see ME Year : 2001 GLP : yes Test substance : other TS Method : Reproduction/developmental toxicity screening test according to OECD TG 421 Result : The test substance had no effect on body weight gain. Food consumption was increased in high-dosed males (only intermittendly) and in all 6PPDtreated females (only during lactation). 6PPD had no adverse effects on the reproductive organs (histologic examination) in any treatment group. Effects/6 mg/kg/d: NOAEL; Effects/25 mg/kg/d: inceased liver weight, vacuolar liver degeneration (males, 2/12), salivation (males); Effects/100 mg/kg/d: 1/12 dams died on gd 23; salivation (both sexes), liver enlargement (both sexes), vacuolar liver degeneration (males, 9/11), increased liver weight (both sexes) and increased adrenal weight (males). Organ weights of rats (g or g%) treated orally with 6PPD: Dose level 0 6 25 100 Liver/abs., males 16.03 17.70 17.84 22.15** Liver/abs., females 11.14 12.11 13.12** 15.24** Liver/rel., males 3.35 3.59 3.69* 4.51** Liver/rel., females 3.98 4.19 4.43** 5.16** Adrenals/abs./males 0.051 0.051 0.053 0.060** Adrenals/abs./fem. 0.073 0.067 0.071 0.079 Adrenals/rel./males 0.010 0.010 0.011 0.012* Adrenals/rel./fem. 0.026 0.023 0.024 0.026 UNEP PUBLICATIONS 113
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N-(1,3-Dimethylbutyl)-N

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