N-(1,3-Dimethylbutyl)-N
N-(1,3-Dimethylbutyl)-N
N-(1,3-Dimethylbutyl)-N
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OECD SIDS<br />
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE<br />
5. TOXICITY ID: 793-24-8<br />
DATE: 11.05.2005<br />
exposure time - 24 hrs: MI 2.0 at 0.020 mg/ml<br />
exposure time - 48 hrs: MI 2.8 at 0.010 mg/ml<br />
exposure time - 6 hrs/-S9mix: MI 11.4 at 0.0025 mg/ml, 0.2<br />
at 0.0050 mg/ml<br />
exposure time - 6 hrs/+S9mix: MI 9.6 at 0.015 mg/ml<br />
Test condition : SYSTEM OF TESTING<br />
- Metabolic activation system: rat liver induced with<br />
phenobarbital and 5,6-benzoflavone<br />
- No. of metaphases analyzed: 200<br />
ADMINISTRATION:<br />
- Number of replicates: 2 plates/test<br />
- Application: continuous treatment 24 and 48 hours only<br />
without metabolic activation; short-term treatment 6 hours<br />
with and without metabolic activation;<br />
- Positive and negative control groups and treatment:<br />
negative control: solvent DMSO<br />
positive control: -S9mix: Mitomycin C; +S9mix:<br />
Cyclophosphamide<br />
CRITERIA FOR EVALUATING RESULTS:<br />
positive: significantly different from solvent control at<br />
p
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