N-(1,3-Dimethylbutyl)-N

OECD SIDS
N-(1,3-DIMETHYLBUTYL)-N´-PHENYL-1,4-PHENYLENEDIAMINE
5. TOXICITY ID: 793-24-8
DATE: 11.05.2005
Method : other
Year : 1983
GLP : no data
Test substance : other TS: technical grade
Result : I.) ED50 (dose/egg) 1.5 umol
maximum malformed: 40 %
II.) dose/egg (umol) affected embryos (early/late deaths,
malformations) in %
0.55 0 (n=10)
1.1 20 (n=30)
2.2 43 (n=30)
4.4 33 (n=30)
Test condition : TS was tested for embryotoxicity and induction of
malformations in three-day chicken embryos
Reliability : (3) invalid
Unsuitable test system
14.10.2001 (106) (107)
5.8.3 TOXICITY TO REPRODUCTION, OTHER STUDIES
5.9 SPECIFIC INVESTIGATIONS
5.10 EXPOSURE EXPERIENCE
Remark : Biomonitoring
Result : In the rubber industry 6PPD was detected in the urine of
6PPD exposed workers. In environmental air levels were in
the range of < 0.01 - 260 ug/mc (peak 6600) and in urine
levels were in the range of < 1 - 300 ug/g creatinine (peak
580). The samples were collected between 1982 and 1987.
Reliability : (2) valid with restrictions
Test procedure in accordance with generally accepted
scientific principles and described in sufficient detail
Flag : Critical study for SIDS endpoint
04.10.2001 (108)
Remark : Monitoring
The authors desribed analytical methods for the
determination of the trace levels of 6PPD in human urine.
In the publication of Pavan et. al. (1987) the abbreviation
6PPD is used however the substance is called
N-(2,3-dimethylpropyl)-N-phenyl-1,4-benzenediamine with the
CAS-No. 739-24-8.
Result : analytical methods for the determination of the trace levels
30.08.2001 (109) (110)
04.10.2001
136
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