ABSTRACTS from 16th International COnference on ... - CRRT Online

<strong>ABSTRACTS</strong> FROM 17 TH INTERNATIONAL CONFERENCE ON CRRT,
SAN DIEGO, FEB 14-17, 2012
females), admitted to the Intensive Care
Unit (ICU) <strong>from</strong> February to November,
211 with AKI requiring CRRT were
monitored up to 5 consecutive days. All
patients received CRRT using Prisma
M1 set with AN69 hemofilter on citrate
anticoagulation with an effluent rate of
25-3 ml/kg/hr. Data, including admission
weight (WT), daily WT and daily fluid
balance calculations, were obtained <strong>from</strong>
electronic medical records and ICU
flowsheets which were compared to
physician prescription orders. Results:
The mean pre-CRRT WT (99. + 25.6 kg)
was markedly increased when compared
to the mean admitting WT (8.2 + 24.9
kg). Mean net negative fluid balance
achieved during the first 48 hours of
CRRT was 36 mL, with a decrease in
mean WT to 98+ 23.1 kg, however this
was not statistically significant. By day
5, a mean reported fluid loss of 3.2 liters
was associated with a significant mean
weight reduction to 92.9+ 25.3 kg (p =
.1). The mean prescribed ultrafiltration
(UF) rate was 35.3+ 28.4 mL/hr while
delivered UF rate was 52.7+ 48.6
mL/h(p=.2). On day 2, the mean fluid
removal set on the Prisma machine was
6.5 L/day while mean net fluid removal
was 6. L/day which was significantly
lower (p=.3). In conclusion, actual
delivered UF during CRRT treatments
exceeded physician prescription orders.
UF goals still need to be optimized.
28. The Effect Of Continuous Renal
Replacement Therapy In Patients
With Acute Kidney Injury on the
serum levels of biomarkers usually
used to indicate renal function
Zhihong Zhang, Dehua Gong, Daxi Ji,
Bin Xu, Zhihong Liu
Research Insitute of Nephrology,Jinling
Hospital
Objective: Continuous veno-venous
hemofiltration(CVVH) can affect the
serum concentrations of usually used
biomarkers to indicate renal function,
like creatinine(Cr), urea(UN) and
cystatin C(Cys-C). In this study we
investigate to what extent CVVH affects
the concentrations of Scr,BUN and Cys-
C independent on renal function change.
Methods: Eleven patients with oliguric
acute kidney injury (AKI) requiring
CVVH were enrolled. Four of them
received CVVH at dose of 2L/hr and 7
received CVVH at dose of 4L/hr.
Samples were obtained <strong>from</strong> the afferent
and efferent lines of the extracorporeal
circuit and <strong>from</strong> the ultrafiltrate line at 4
different time points(,4,12 and 24h) for
measurement of Cr, UN and Cys C.
Results: Concentrations of Scr, BUN
and Cys-C before CVVH (2 L/hr) were
4.84±2.51, 57.35±31.33mg/dl and
4.34±1.33 mg/L. Levels of Scr, BUN
and Cys-C at 4,12 and 24h during
CVVH (2 L/hr) gradually decreased
<strong>from</strong> the baseline values. The decreases
of Scr, BUN and Cys-C were
49.7%,42.5% and 28.1%(all P>.5). The
mean sieving coefficient of Scr,BUN
and Cys-C were .89, .78 and .32;the
mean clearance of Scr, BUN and Cys-C
were 29.7, 26 and 1.7mL/min.
Concentrations of Scr,BUN and Cys-C
before CVVH (4 L/hr) were 6.9±4.13,
94.3±57.4 mg/dl and 3.7±1.4 mg/L.
Levels of Scr, BUN and Cys-C at 4,12
and 24h during CVVH (4L/hr) were
gradually decreased <strong>from</strong> the baseline
values. The maximum decreases of
Scr,BUN and Cys-C were 57.8%(
P=.39),51.% and 26.6%(all P>.5). The
mean the sieving coefficient of Scr,
BUN and Cys-C were .82, .97and .51;the
mean clearance of Scr,BUN and Cys-C
were 54.7, 64.6 and34.mL/min.
Conclusion: Compared with Scr and
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