ABSTRACTS from 16th International COnference on ... - CRRT Online

<strong>ABSTRACTS</strong> FROM 17 TH INTERNATIONAL CONFERENCE ON CRRT,
SAN DIEGO, FEB 14-17, 2012
Although not statistically significant,
there appears to be differences in
NGAL, KIM-1, OPN and albumin at
different days between those with AKI
and those without AKI. Conclusions:
Urinary biomarkers can predict AKI
term neonates with perinatal depression
independent of gestational age.
30. Prevention of Acute Kidney Injury
in Hospitalized Children with
Cystic Fibrosis
David Askenazi, Adam W Scott,
LaCrecia J Britton, Hector Gutierrez,
Raymond Lyrene
University of Alabama at Birmingham
Introduction: Aminoglycosides (AGs)
are commonly used to treat cystic
fibrosis (CF) related lung infections.
AGs are nephrotoxic and are an
important risk factor for acute kidney
injury (AKI) in hospitalized CF patients.
In June 29, a new clinical protocol was
implemented to reduce the incidence of
AKI by standardizing monitoring and
AG treatment in all CF patients admitted
to Children’s Hospital of Alabama for
pulmonary exacerbations. Hypothesis:
We hypothesized that the incidence of
AKI in hospitalized children with CF
would decrease after the implementation
of this clinical protocol. Methods: A
retrospective chart review was
performed using data <strong>from</strong> the
UAB/Children’s of Alabama’s Cystic
Fibrosis Center database and hospital
records for all admissions of CF patients
with pulmonary exacerbations <strong>from</strong> July
27 to April 211.These data include
demographics, co-morbidities, and
serum creatinines (SCr). Hospitalized
costs were obtained <strong>from</strong> the Children’s
of Alabama for cost analysis. AKI was
defined as a rise in SCr of .3 mg/dl or
5% rise <strong>from</strong> a baseline value, according
to the 211 Kidney Disease Improving
Global Outcomes (KDIGO) AKI
definition. Data analysis was performed
using SPSS® software. IRB approval for
the study was obtained. Results: The
incidence of AKI was lower in the preprotocol
group 96/ 631 (15.2%)
compared to the post-protocol group
113/ 475 (23.8%) (p