ABSTRACTS from 16th International COnference on ... - CRRT Online
ABSTRACTS from 16th International COnference on ... - CRRT Online
ABSTRACTS from 16th International COnference on ... - CRRT Online
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Physiological and Imaging Markers of AKI<br />
Mark D. Okusa MD<br />
3:00-3:15<br />
Thursday, February 16<br />
Educati<strong>on</strong>al Objectives:<br />
To describe the importance of physiological biomarkers of AKI<br />
To describe different imaging methods to study GFR, renal blood flow and kidney oxygenati<strong>on</strong> in AKI.<br />
C<strong>on</strong>tent Descripti<strong>on</strong>:<br />
The Acute Dialysis Quality Initiative (ADQI) C<strong>on</strong>sensus C<strong>on</strong>ference <strong>on</strong> “Acute Kidney Injury Biomarkers” was<br />
held in Dublin, Ireland, in August 2011 (www.adqi.net), attended by an internati<strong>on</strong>al group of experts, focusing<br />
<strong>on</strong> an objective scientific review of the current literature, developing a c<strong>on</strong>sensus of opini<strong>on</strong>, with evidence<br />
where possible, <strong>on</strong> best practice, and articulating a research agenda to focus <strong>on</strong> important unanswered questi<strong>on</strong>s.<br />
Four breakout groups focused <strong>on</strong> the use of biomarkers in AKI. This presentati<strong>on</strong> will focus <strong>on</strong> the role of imaging<br />
and physiological markers for the study of human AKI. This presentati<strong>on</strong> will summarize the current stateof-the<br />
art of the available techniques for m<strong>on</strong>itoring kidney oxygenati<strong>on</strong>, perfusi<strong>on</strong> and metabolism at the bedside,<br />
and potentially illuminate a road map to provide a reliable and quantifiable platform for the measurement of<br />
renal physiological biomarkers related to oxygenati<strong>on</strong>.<br />
Suggested Reading:<br />
Klibanov AL. Ultrasound c<strong>on</strong>trast agents: Development of the field and current status. Top Curr Chem<br />
2002;222:73-106.<br />
Rabito, C. A., S. van T<strong>on</strong>geren, et al. (2010). "Measurement of glomerular filtrati<strong>on</strong> rate in anesthetized and c<strong>on</strong>scious<br />
rhesus m<strong>on</strong>keys (Macaca mulatta)." Am J Vet Res 71(12): 1492-1499.<br />
Le Dorze, M., M. Legrand, et al. (2009). "The role of the microcirculati<strong>on</strong> in acute kidney injury." Curr Opin<br />
Crit Care 15(6): 503-508.<br />
Deruddre, S., G. Cheiss<strong>on</strong>, et al. (2007). "Renal arterial resistance in septic shock: effects of increasing mean<br />
arterial pressure with norepinephrine <strong>on</strong> the renal resistive index assessed with Doppler ultras<strong>on</strong>ography."<br />
Intensive Care Med 33(9): 1557-1562.<br />
Kalantarinia, K., J. T. Belcik, et al. (2009). "Real-time measurement of renal blood flow in healthy subjects using<br />
c<strong>on</strong>trast-enhanced ultrasound." Am J Physiol Renal Physiol 297(4): F1129-1134.<br />
Inoue, T., E. Kozawa, et al. (2011). "N<strong>on</strong>invasive evaluati<strong>on</strong> of kidney hypoxia and fibrosis using magnetic res<strong>on</strong>ance<br />
imaging." Journal of the American Society of Nephrology : JASN 22(8): 1429-1434.<br />
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